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Anwendungsbeispiele der direkten HPLC-NMR-Kopplung mit hoher Auflösung

Examples of application of direct HPLC-NMR-coupling with high resolution

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Summary

With the direct on-line coupling of HPLC-NMR, simultaneous separation and identification in the liquid phase of components in a mixture is possible. Examples carried out on some aromatic compounds as well as steroids show the wide scope of application of this method with either a continuous flow or a stop flow technique. A mathematical resolution enhancement technique is utilized to improve the on-line NMR spectra substantially.

Zusammenfassung

Durch HPLC-NMR on-line Kopplung ist eine gleichzeitige Trennung und Identifizierung von Komponenten eines Substanzgemisches möglich. Trennbeispiele von Aromaten und Steroiden zeigen die mögliche Anwendungsbreite der Methode durch Messung im Durchfluß-bzw. stop-flow-Verfahren. Durch Verwendung einer mathematischen Filter-Funktion kann annähernd die Qualität von herkömmlichen Routine-Spektren erzielt werden.

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Authors and Affiliations

  1. Inst. f. Org. Chemie der Univ., Auf der Morgenstelle 18, D-7400, Tübingen 1

    E. Bayer, K. Albert, M. Nieder, E. Grom & Zhu An

  2. Inst. of Chemistry, Academica Sinica, Zhong Guang Cun, Beiging, VR China

    Zhu An

Authors
  1. E. Bayer
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  2. K. Albert
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  3. M. Nieder
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  4. E. Grom
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  5. Zhu An
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Bayer, E., Albert, K., Nieder, M. et al. Anwendungsbeispiele der direkten HPLC-NMR-Kopplung mit hoher Auflösung. Z. Anal. Chem. 304, 111–116 (1980). https://doi.org/10.1007/BF00474367

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  • DOI: https://doi.org/10.1007/BF00474367

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