Conclusions
The new radioimmunoassay RIA-mat Theophylline appeared to be highly specific, as none of the drugs structurally related to theophylline or other substances tested showed a noticeable cross reaction. Precision and accuracy are better than comparable assays, the sensitivity of detection is much better than e.g. if using an enzyme immunoassay.
Since the required reagents are available as ready-to-use solutions, it is possible to run individual determinations e.g. in emergency cases, as well as large series in a very brief period of time.
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References
Aranda, J. V., Sitar, D. S., Parson, W. D., Longhan, P. M., Neims, A. H.: Clin. Res. 23, 608 (1975)
Herrmann, G., Aynesworth, M. B.: J. Lab. Clin. Med. 23, 135–148 (1937)
Wilson, A. F., McPhillips, J. J.: Ann. Rev. Pharmacol. Toxicol. 18, 541 (1978)
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Zech, K., Borner, K. & Stetten, O.v. Monitoring of serum or saliva theophylline concentrations by a new radioimmunoassay. Z. Anal. Chem. 301, 114 (1980). https://doi.org/10.1007/BF00467761
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DOI: https://doi.org/10.1007/BF00467761