Akustisch evozierte Hirnstamm- und Rindenpotentiale bei Sedierung mit Diazepam

Summary

In an investigation with 11 subjects of normal hearing ability the influence of Diazepam on the acustically evoked responses was examined. The brainstem and the cortical responses were recorded without sedation as well as after a first and a second i.v. application of 0.1 mg/kg body weight Diazepam. Simultaneously the degree of sedation was evaluated by means of an adjective check-list and was correlated with the Diazepam concentration in the serum and the amount of the electrical activity of the brain, which was recorded by a specially developed technique.

No significant modifications were found in the BER whereas in the CER the latencies of the N1 and P2 waves were extended with increasing sedation. The electrical activity recorded proved to be useful for measuring on line the actual signal to noise ratio while recording the BER and for estimating the advantages to be expected from sedation.