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Development of self-spouting and vacuum nebulizing assisted interface for direct coupling of a micro-liquid chromatograph with a mass spectrometer and some applications to thermally labile compounds

Entwicklung eines Interface mit verstärktem Sprüheffekt und Vakuum-Nebuliser zur direkten Kopplung eines Mikro-Flüssig-Chromatographen mit einem Massenspektrometer sowie einige Anwendungen auf thermisch labile Verbindungen

  • Original Papers
  • Mass Spectrometric Techniques
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Zusammenfassung

Bei dem neu entwickelten Interface wird das Effluat des Chromatographen durch eine Capillardüse von 12 μm i.D. gedrückt, wird fein versprüht und durch Erhitzen unter Vakuum von Lösungsmittel befreit. Ein Teil des Nebels wird kontinuierlich in die Ionenquelle (mit chemischer Ionisierung) eines Quadrupol-Massenspektrometers eingeführt und die Massenspektren und/oder Massenchromatogramme werden registriert. Das neuartige System wurde mit Erfolg auf verschiedene thermisch labile und/oder polare Verbindungen angewendet, z.B Polyethylenglykole, Vitamine und Saccharide.

Summary

A self-spouting and vacuum nebulizing assisted interface was newly developed for the direct coupling of a micro-liquid chromatograph and a mass spectrometer (LC/ MS). The effluent from the micro-LC is enforced to spout through a glass capillary nozzle with 12 μm i.d. The self-spouting effluent is finely nebulized and desolvated by heating under vacuum. A portion of the enriched mist or vapor of the effluent is continuously introduced into the chemical ionization source of a quadrupole mass spectrometer to monitor the mass spectra and/or the mass chromatograms of the sample solutes. The newly constructed LC/MS system was successfully applied to various thermally labile and/or polar compounds such as polyethylene glycols, vitamins and saccharides.

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Authors and Affiliations

  1. Department of Synthetic Chemistry, Faculty of Engineering, Nagoya University, 464, Nagoya, Japan

    K. Matsumoto, H. C. Lieu & S. Tsuge

Authors
  1. K. Matsumoto
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  2. H. C. Lieu
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  3. S. Tsuge
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Matsumoto, K., Lieu, H.C. & Tsuge, S. Development of self-spouting and vacuum nebulizing assisted interface for direct coupling of a micro-liquid chromatograph with a mass spectrometer and some applications to thermally labile compounds. Z. Anal. Chem. 323, 212–216 (1986). https://doi.org/10.1007/BF00464075

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  • DOI: https://doi.org/10.1007/BF00464075

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