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Einfluß der hämodialyse auf die somatosensibel evozierten potentiale bei urämiepatienten

Changes of somatosensory evoked potentials in uremic patients due to hemodialysis

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Summary

Spinal and cortical potentials in response to unilateral stimulation of the median nerve of the wrist were recorded in 13 uremic patients, 1 h prior to and 1 h after dialysis. A comparison of the data from these patients with those of a control group revealed a slowing of impulse conduction in the peripheral nerve only, whereas the central part of the somatosensory system was not affected. Amplitudes of the evoked potentials tended to increase after dialysis. This could be due to a decrease of descending inhibition or a transitory change of the resting membrane potential caused by the elimination of dialyzable substances.

Zusammenfassung

Bei 13 Urämie-Patienten erfolgten Ableitungen der zervikalen und kortikalen somatosensibel evozierten Potentiale nach Medianusstimulation, jeweils eine Stunde vor Beginn bzw. nach Beendigung der Dialyse. Ein Vergleich der Urämie-Patienten mit einem Normalkollektiv ergab eine ausschließiche Beeinträchtigung der Impulsleitung im Bereich des peripheren Nervensystems, während der zentrale Anteil des somatosensiblen Systems durch die chronische Niereninsuffizienz nicht gestört zu sein scheint.

Innerhalb der Gruppe der Urämie-Patienten wiesen die Amplituden der evozierten Potentiale nach der Dialyse eine Tendenz zur Erhöhung auf. Mögliche Erklärungen hierfür sind eine Aktivitätsabnahme deszendierender inhibitorischer Mechanismen oder passagere Änderungen des Ruhemembranpotentials im Zusammenhang mit der Eliminierung dialysabler Substanzen.

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Authors and Affiliations

  1. Neurologische Universitätsklinik Tübingen, Liebermeisterstraße 18-20, D-7400, Tübingen, Bundesrepublik Deutschland

    G. Niemann

  2. Neurologische Klinik mit Abteilung für klinische Neurophysiologie, Zentralklinikum, Stenglinstraße, D-8900, Augsburg, Bundesrepublik Deutschland

    M. Stöhr

  3. Abteilung Innere Medizin III, Medizinische Universitätsklinik Tübingen, Otfried-Müller-Straße, D-7400, Tübingen, Bundesrepublik Deutschland

    G. A. Müller

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Niemann, G., Stöhr, M. & Müller, G.A. Einfluß der hämodialyse auf die somatosensibel evozierten potentiale bei urämiepatienten. Eur Arch Psychiatr Neurol Sci 234, 184–188 (1984). https://doi.org/10.1007/BF00461559

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  • DOI: https://doi.org/10.1007/BF00461559

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