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Zur Ausbreitung von Fluorescein im Innenohr nach Applikation in das Mittelohr

Distribution of fluorescein in the inner ear after application into the middle ear

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Summary

A solution of 2% fluorescein in buffered physiological saline was applied into the middle ear of young healthy pigmented guinea pigs. In one series of experiments the whole middle ear was filled. In a second series the round and oval windows were left uncovered. At different time intervals after application the inner ear was frozen by liquid air and the specimen cut in a cryotom.

Fluorescein quickly reached the subarachnoidal space from the first coil of the scala tympani (about 10 min). From the lower cochlear duct the substance was carried to the endolymphatic sac in about 30 min. Fluorescein penetrated the cochlear bone in all turns and was found in endolymph and perilymph. From the upper coils the substance spread slowly basalwards in all three scales. In all cases fluorescein was seen in the modiolus.

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Authors and Affiliations

  1. Tübingen

    W. Giebel, U. Pfeil a. G. & B. Schmid a. G.

Authors
  1. W. Giebel
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  2. U. Pfeil a. G.
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  3. B. Schmid a. G.
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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft

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Giebel, W., Pfeil, U. & Schmid, B. Zur Ausbreitung von Fluorescein im Innenohr nach Applikation in das Mittelohr. Arch Otorhinolaryngol 235, 650–654 (1982). https://doi.org/10.1007/BF00459959

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  • DOI: https://doi.org/10.1007/BF00459959

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