Zusammenfassung
Die Aufnahme von Deoxyglukose in das Innenohrgewebe wurde bei Mäusen untersucht. Sechzig Minuten nach einmaliger i.v. Injektion von 5 mCi 2-Deoxy-D[3H]-Glukose/kg Körpergewicht wurden Stria vascularis/Ligamentum spirale und Cortisches Organ sowie andere Körpergewebe seziert und ihre Radioaktivität gemessen. Die Aufnahme in das Innenohrgewebe war 3–5mal niedriger als in Herz oder Gehirn. Das Verhältnis von Deoxyglukose-6-Phosphat zu Deoxyglukose war 60∶40, und die Substanzen wurden mit einer kurzen Halbwertszeit (ca. 60 min) aus dem Innenohr ausgeschieden. Beschallung mit white noise (100 dB) während des radioaktiven Pulses führte zu einer 50%igen Erniedrigung der Einbaurate in die Innenohrgewebe.
Summary
The uptake of deoxyglucose into inner ear tissues was studied in the mouse. Sixty minutes after a single i.v. injection of 5 mCi 2-deoxy-D-[3H]glucose/kg body weight, stria vascularis/spiral ligament and organ of Corti as well as other body tissues were dissected and analyzed for radioactivity. Uptake into inner ear tissues was three to five times lower than into brain or heart. The ratio of deoxyglucose-6-phosphate to deoxyglucose was 60∶40 and the compounds were eliminated from the inner ear with a half life of approximately 60 min. Exposure to 100 dB of white noise during the radioactive pulse decreased uptake of deoxyglucose into both stria vascularis/spiral ligament and organ of Corti by 50%.
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This work was supported by grant NS 12881 from the National Institutes of Health and Program Project grant NS 05785 and training grant NS 07106
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Canlon, B., Schacht, J. The effect of noise on deoxyglucose uptake into inner ear tissues of the mouse. Arch Otorhinolaryngol 230, 171–176 (1981). https://doi.org/10.1007/BF00456146
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DOI: https://doi.org/10.1007/BF00456146