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Decrease in neutrophils observed in vivo in psoriatics after PUVA therapy

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Summary

In 56 patients leucocyte and differential counts were done before and at weekly intervals during PUVA treatment of chronic recalcitrant psoriasis. A statistical significant (P<0.01) decrease in the percentage of neutrophils was observed during the first week of the PUVA therapy. This observation could be closely related to the clinical clearing of psoriasis (P=0.02).

The effect of PUVA therapy in psoriasis may be due to a decrease in the number of immunocompetent neutrophils demonstrated in psoriatic lesions.

Zusammenfassung

56 Patienten mit chronischer behandlungsresistenter Psoriasis wurden mit PUVA behandelt. Unmittelbar vor Behandlungsanfang und danach einmal wöchentlich wurde eine qualitative und quantitative Bestimmung des weißen Blutbildes vorgenommen.

Die Konzentration neutrophiler Granulocyten fiel während der ersten Behandlungswoche signifikant (P<0,01) und korrelierte wohl mit den klinischen Behandlungseffekt (P=0,02).

Der Effekt der PUVA Behandlung beruht möglicherweise auf einer Reduktion der Anzahl immunokompetenter neutrophiler Granulocyten in den Psoriasis-Plaques.

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Authors and Affiliations

  1. Department of Dermatology, the Finsen Institute, 49 Strandboulevarden, DK-2100, Copenhagen Ø, Dermark

    K. B. Dahl, A. Nyfors & H. Brodthagen

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  1. K. B. Dahl
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  2. A. Nyfors
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  3. H. Brodthagen
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Dahl, K.B., Nyfors, A. & Brodthagen, H. Decrease in neutrophils observed in vivo in psoriatics after PUVA therapy. Arch Dermatol Res 262, 131–134 (1978). https://doi.org/10.1007/BF00455580

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  • DOI: https://doi.org/10.1007/BF00455580

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