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Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema

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Summary

Plasma kinin formation after in vitro activation of factor XII in the coagulation system was examined in 4 patients with hereditary angioneurotic edema. Compared to controls activationcurves showed a steeper increase and higher maximum levels. Administration of tranexamic acid to the patients resulted in partial normalisation of plasma kinin activation.

Zusammenfassung

Die Plasmakininbildung nach in vitro-Aktivation des Faktors XII im Gerinnungssystem wurde bei 4 Patienten mit hereditärem angioneurotischem Ödem untersucht. Verglichen mit den Kontrollen, zeigten die Aktivkurven einen steileren Anstieg und einen höheren maximalen Spiegel. Die Verabreichung von Tranexansäure, eine der Epsilonaminocapronsäure analoge Verbindung, fürhrte zur teilweisen Normalisation der Plasmakininaktivierung.

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References

  1. Champion, R. H., Lachmann, P. J.: Hereditary angio-oedema treated with E-aminocaproic acid. Brit. J. Derm. 81, 763–765 (1969)

    Google Scholar 

  2. Donaldson, V. H., Evans, R. R.: A biochemical abnormality in hereditary angioneurotic edema. Abscence of serum inhibitor of C1-esterase. Amer. J. Med. 35, 37–44 (1963)

    Google Scholar 

  3. Erdös, E. G., Renfrew, A. G., Sloane, E. M., Wohler, J. R.: Enzymatic studies on bradykinin and similiar peptides. Ann. N. Y. Acad. Sci. 140, 222–235 (1963)

    Google Scholar 

  4. Gigli, I., Mason, J. W., Colman, R. W., Austen, K. E.: Interaction of plasma kallikrein with the C1-inhibitor. J. Immun. 104, 574–581 (1970)

    Google Scholar 

  5. Henningsen, S. J., Zachariae, H.: Glucocorticoids and Hageman factor activation of human plasma kallikrein. J. invest. Derm. 54, 196–199 (1969)

    Google Scholar 

  6. Lundh, B., Laurell, A. B., Wetterquist, H., White, T., Granerus, G.: A case of hereditary angioneurotic oedema, succesfully treated with E-aminocaproic acid. Clin. Exp. Immun. 3, 733–745 (1968)

    Google Scholar 

  7. Sheffer, A. L., Austen, K. F., Rosen, F.: Tranexamic acid therapy in hereditary angioneurotic edema. N. Engl. J. Med. 287, 452–454 (1972)

    Google Scholar 

  8. Webster, M. E., Ratnoff, O. D.: Role of Hagman factor in the activation of vasodilatator activity in human plasma. Nature (Lond.) 192, 180–181 (1961)

    Google Scholar 

  9. Zachariae, H., Laurberg, G., Hjortshøj, A.: Tranexamic acid (Cyklokapron®) in hereditary angioneurotic edema. Ugeskr. Læg. 137, 1106–1108 (1975)

    Google Scholar 

  10. Zachariae, H., Malmquist, J., Oates, J., Pettinger, W.: Studies on the mechanism of kininformation in inflammation. J. Physiol. 190, 81–90 (1967)

    Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Marselisborg Hospital, University of Aarhus, Aarhus, Denmark

    Grete Lauerberg

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  1. Grete Lauerberg
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Lauerberg, G. Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema. Arch Dermatol Res 262, 153–156 (1978). https://doi.org/10.1007/BF00455384

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  • DOI: https://doi.org/10.1007/BF00455384

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