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Vascular perfusion of the cochlea: Effect of potassium-free and rubidium-substituted media

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Summary

By means of vascular perfusion of the cochlea with K+-free synthetic blood, it is possible to maintain the endocochlear potential (EP) at normal or supernormal levels for periods of 20–42 min. The subsequent decline of the EP is comparatively slow. This is in contrast to the immediate onset and rapid decline of the EP during perilymphatic perfusion with K+-free media. Possible implications of these data concerning the mode of generation of the EP are briefly discussed. It is further shown, that synthetic blood, in which K+ is replaced by Rb+, maintains the EP at normal or near normal levels for 2 h.

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References

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Author notes

  1. J. Wada

    Present address: Dept. of Otolaryngology, Tohoku University Medical School, Sendai, Japan

Authors and Affiliations

  1. Dept. of Otolaryngology, Washington University Medical School, 517 S. Euclid, 63110, St. Louis, MO, USA

    J. Wada, J. Kambayashi, D. C. Marcus & R. Thalmann

Authors
  1. J. Wada
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  2. J. Kambayashi
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  3. D. C. Marcus
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  4. R. Thalmann
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Additional information

Supported by NIH grant NS 06575 and NSF grant BNS 77-16842

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Wada, J., Kambayashi, J., Marcus, D.C. et al. Vascular perfusion of the cochlea: Effect of potassium-free and rubidium-substituted media. Arch Otorhinolaryngol 225, 79–81 (1979). https://doi.org/10.1007/BF00455206

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  • DOI: https://doi.org/10.1007/BF00455206

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