Zusammenfassung
In einer histochemischen und ultrastrukturellen Untersuchung werden die pathologischen Bindegewebsveränderungen bei der Otosklerose analysiert. Die Erkrankung führt zu einer komplexen Schädigung aller Bindegewebskomponenten. Es finden sich morphologische Anhalte für einen Enzymdefekt, der dem initialen pathologischen Reiz aufgelagert sein kann. Die beobachtete chondrozytäre Chondrolyse unterstreicht die Bedeutung der Knorpelreste in der otischen Kapsel als pathogenetischen Faktor der Otosklerose.
Summary
In a histochemical and electron microscopical study the pathogenesis of Otosclerosis was investigated. The morphological changes in the extra- and intracellular space indicated a complex metabolic disturbance of all tissue components. The observed chondrocytic chondrolysis stressed the role of the cartilage remnants in the otic capsule as an etiological factor. There was morphological evidence of a superimposed enzymatic defect.
References
Ali SY (1977) Matrix vesicles and apatite nodules in arthritic cartilage. In: Willoughby DA, Giroud JP, Velo CP (eds): Perspectives in inflammation. MTP Press Ltd, Lancaster, UK, p 211
Altmann F, Glasgold A, Macduff JP (1967) The incidence of otosclerosis as related to race and sex. Ann Otol 76:377
Anderson HC (1976) Matrix vesicles of cartilage and bone. In: Bourne GH (ed): The biochemistry and physiology of bone. Vol IV, Academic Press, New York, p 135
Anson BJ, Cauldwell EW, Bast TH (1948) The fissula ante fenestram of the human otic capsule. Ann Otol 57:103
Arnold W (1976) Veränderungen im Bereich der Mittelohrschleimhaut bei der Otosklerose. Acta Otolaryngol 81:185
Arnold W, Plester D (1977) Histologische und klinische Aspekte bei florider Otospongiose der Steigbügel-Fußplatte mit Beziehung zur Perilymphe. Arch Oto-Rhino-Laryngol 215:159
Bretlau P (1971) Otosclerosis. Electron microscopic studies of biopsies from the labyrinthine capsule. Arch Otolaryngol 93:551
Chevance LG, Bretlau P, Jørgensen MB, Causse J (1970) Otosclerosis. An electron microscopic and cytochemical study. Acta Otolaryngol (Suppl) 272:5
Fullmer HM, Lillie RD (1958) The oxytalan fiber: A previously undescribed connective tissue fiber. J Histochem Cytochem 6:425
Fullmer HM, Sheetz JB, Narkates AJ (1974) Oxytalan connective tissue fibres: A review. J Oral Pathol 3:291
Guild IR (1944) Histologic otosclerosis. Ann Otol 53:246
Hall DA (1976) The ageing of connective tissue. Academic Press, London, New York, San Francisco
Höhling HJ, Steffens H, Stamm G (1976) Transmission microscopy of freeze dried unstained epiphyseal cartilage of the guinea pig. Cell Tissue Res 167:243
Holdsworth CE, Endahl GL, Soifer N, Richardson KE (1973) Aberrant behavior of phosphofructokinase from otosclerotic stapedes. Arch Otolaryngol 98:191
Jonas I, Riede UN (1979) Der Einfluß von Flavichromin auf das orthodontisch stimulierte Parodontium. Fortschr Kieferorthop 40:70
Kosokabe (1922) In: Müller E (1959) Schalleitungsschwerhörigkeiten. Ihre Ursachen und Entstehung. Thieme, Stuttgart
Lim DJ, Saunders WH (1975) Active otosclerotic foci in the stapes. Acta Otolaryng 80:255
Lindsay JR (1973) Histopathology of otosclerosis. Arch Otolaryngol 97:24
Mann W, Riede UN, Jonas I, Beck Chl (1980) The role of matrix vesicles in the pathogenesis of tympanosclerosis. Acta Otolaryngol 89:43
Morrison AW (1967) Genetic factors in otosclerosis. Ann Roy Coll Surg Engl 41:202
Müller E (1959) Schalleitungsschwerhörigkeiten. Ihre Ursachen und Entstehung. Thieme, Stuttgart
Nylen B (1949) Histopathological investigations on the localization, number activity, and extent of otosclerotic foci. Uppsala Läk-Fören Förh 51:1
Rabinovitch AL, Anderson C (1976) Biogenesis of matrix vesicles in cartilage growth plates. Fed Proc 35:112
Rannie I (1963) Observations on the oxytalan fibre of the periodontal membrane. Trans Eur Orthod Soc p 127
Riede UN, Staubesand J (1977) A unifying concept for the role of matrix vesicles and lysosomes in the formal pathogenesis of diseases of connective tissues and blood vessels. Beitr Pathol 160:3
Romeis B (1968) Mikroskopische Technik. 16th ed., R. Oldenbourg, München Wien
Rüedi L (1963) Pathogenesis of otosclerosis. Arch Otolaryngol 78:469
Shambaugh GE (1959) Surgery of the ear. Saunders, Philadelphia — London
Silverberg R (1971) Wachstum und Altern des Skeletts. Acta Rheumatol (Suppl) 26
Soifer N, Weaver K, Endahl GL, Holdsworth CE Jr (1970) Otosclerosis. A review. Acta Otolaryngol (Stockh) (Suppl) 269
Spycher MA, Moor H, Ruettner JR (1969) Electron microscopic investigations on aging and osteoarthrotic human artìcular cartilage. II. The fine structure of freeze-etched aging hip joint cartilage. Z Zellforsch 98:512
Staubesand J (1976) Nachweis intra- und extrazellulärer Lysosomen in der haemodynamisch fehlbelasteten Arterienwand der Ratte. Verh Dtsch Ges Path 60:148
Thyberg J (1974) Electron microscopic studies on the initial phases of calcification in guinea pig epiphyseal cartilage. J Ultrastruct Res 46:206
Turnbridge R, Tattersall RN (1952) The fibrous structure of normal and abnormal skin. Clin Sci 11:315
Wuthier RE (1976) Lipids of matrix vesicles. Fed Proc 35:117
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Mann, W., Jonas, I., Riede, U.N. et al. A Contribution to the pathogenesis of otosclerosis. Arch Otorhinolaryngol 226, 161–176 (1980). https://doi.org/10.1007/BF00455131
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DOI: https://doi.org/10.1007/BF00455131