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Immunological therapy of recurrent urinary tract infections with immunoactive E. coll fractions in women

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Abstract

The efficacy of Uro-Vaxom®, an orally administered immunostimulatory extract of E. coli, was studied in 89 female patients with recurrent urinary tract infection (UTI). 74 patients with lower UTI and 15 with upper UTI were treated for 3 months with Uro-Vaxom®, 1 capsule daily, initially administered together with an antimicrobial at conventional dosage. During a follow up period of 6 months there was a statistically significant decrease in the incidence of reinfection in patients with lower UTI. During a further observation period of 6–18 months, the protective action of Uro-Vaxom® gradually diminished. An extension of the infection-free interval was registered in 18 patients with lower UTI who received a booster with Uro-Vaxom® 3 months after discontinuation of the initial immunostimulation, these patients showing the lowest recurrence rate. Uro-Vaxom® was well tolerated, with temporarily slight gastrointestinal side effects in only 2 patients.

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  1. Consultant Urologist, Myliusstrasse 25a, D-6000, Frankfurt am Main 1, Germany

    E. W. Rugendorff

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  1. E. W. Rugendorff
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Rugendorff, E.W. Immunological therapy of recurrent urinary tract infections with immunoactive E. coll fractions in women. Int Urogynecol J 3, 179–184 (1992). https://doi.org/10.1007/BF00454997

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