Summary
Measurement of P O 2,P CO 2,and blood flow in skeletal muscle could be a supplement to examination in clinical practice. Mass spectrometry was utilized to measure these parameters in the resting anterior tibial muscle of healthy adults. The partial pressures of oxygen and carbon dioxide were 21 ± 3.6 and 46 ± 2.5 Torr, respectively. The intracompartmental pressure was 8 ± 1.1 Torr. The oxygen tension in muscle varied only slightly when arterial partial pressure was increased. The blood flow (tissue perfusion coefficient) estimated by washout of an inert gas was 5.4 ± 0.8 ml/100 g/min. The results are in accordance with those from animal studies of skeletal muscle. The study demonstrates the feasibility of measuring P O 2,P CO 2,and blood flow in skeletal muscle by mass spectrometry.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allen MJ, Stirling AJ, Crawsford CV, Barnes MR (1985) Intracompartmental pressure monitoring of leg injuries. J Bone Joint Surg [Br] 67:53–57
Cutajar CL, Brown NJG, Marston A (1971) Muscle blood flow studies by the technetium (99mT)CO clearance technique in normal subjects and in patients with intermittent claudication. Br J Surg 58:532–537
Duran WN, Renkin EM (1974) Oxygen consumption and blood flow in resting mammalian skeletal muscle. Am J Physiol 226(1):173–177
Furose A, Brawley RK, Struve E, Gott VL (1974) Skeletal muscle gas tension: indicator of cardiac output and peripheral tissue perfusion. Surgery 74(2):214–222
Holzman GB, Wagner HN, Iio M, Rabinovitz D, Zierler KL (1964) Measurement of muscle blood flow in the human forearm with radioactive krypton and xenon. Circulation 30 (27):7–29
Lassen NA (1967) On the theory of the local clearance method for measurement of blood flow including a discussion of its application to various tissues. Acta Med Scand [Suppl] 472:136–145
Lassen NA, Pearl W (1979) The volume flow and mass flux ratio of an open system. In: Tracer kinetic methods in medical physiology. Raven, New York, pp 62–75
Lundsgaard JS, Jensen B, Grønlund J (1980) Fast-responding flow-independent blood gas catheters for oxygen measurements. J Appl Physiol 48:376–381
Reneman RS (1975) The anterior and the lateral compartmental syndrome of the leg due to intensive use of the muscles. Clin Orthop 113:69–80
Sheridan SW, Matsen FA, Krugmire RB Jr (1977) Further investigations on the pathophysiology of the compartmental syndrome. Clin Orthop 123:266–270
Svalastoga F, Grønlund J (1985) Experimental osteoarthritis in the rabbit. III. Acute osteoarthritis: subchondral P o, 2and oxygen consumption and diffusion capacity in the synovial membrane. Acta Vet Scand 26:340–351
Tønnesen KH, Sejersen P (1970) Washout of 133xenon after intramuscular injection and direct measurement of blood flow in skeletal muscle. Scand J Clin Invest 25:71–81
Tønnesen KH (1969) The blood flow in skeletal muscle during work measured by 133xenon clearance from a local deposit (in Danish). Thesis, University of Copenhagen
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kiær, T., Kristensen, K.D. Intracompartmental pressure, P o 2,P co 2and blood flow in the human skeletal muscle. Arch. Orth. Traum. Surg. 107, 114–116 (1988). https://doi.org/10.1007/BF00454498
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00454498