Zusammenfassung
Histologische Untersuchung des Effektes von Kanamyzin auf die Sinneszellen des Cortischen Organs beim Feten von Albinomeerschweinchen. Kanamyzin (200 oder 400 mg/kg über 8 Tage) wurde den schwangeren Müttern zu verschiedenen Zeiten der Schwangerschaft i.m. injiziert. Als Ergebnis zeigte sich, daß die Stärke der Sinneszellschädigung in der frühen Schwangerschaft stärker ist als in deren letztem Drittel.
Summary
The effect of kanamycin on the cochlear sensory epithelium of albino guinea pig fetuses was studied histologically following the administration of 200 or 400 mg/kg body weight kanamycin sulfate to the pregnant mothers for 8 consecutive days at different stages of gestation. Surface view analysis of Corti's organ revealed slight damage following treatment in the middle trimester of gestation and marked damage due to treatment in the last trimester. The pattern of hair cell loss induced during and after the functional differentiation of the cochlea resembled the pattern of ototoxic lesions in the adult ear. The assumed mechanisms for induction of teratogenesis by kanamycin in the fetal organ of Corti are discussed.
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Established investigator of the Chief Scientist's Bureau, Ministry of Health, Israel
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Raphael, Y., Fein, A. & Nebel, L. Transplacental kanamycin ototoxicity in the guinea pig. Arch Otorhinolaryngol 238, 45–51 (1983). https://doi.org/10.1007/BF00453740
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DOI: https://doi.org/10.1007/BF00453740