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Artificial activation and degeneration of the cochlear nerve in guinea pigs

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Summary

Degeneration of the cochlear nerve was produced in guinea pigs after treatment with high doses of ototoxic antibiotics completely destroying the cochlear receptor. An effective electric stimulation of the inner ear inducing evoked potentials at the auditory cortex was applied over a period of 3.5 months in half of the animals, while the other half was kept for control. The artificial stimulation had no effect on the sensitivity of the inner ear to electric stimulation and did not modify the extent of degeneration of the cochlear nerve.

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Authors and Affiliations

  1. Laboratoire d'Audiologie Expérimentale, INSERM Unité 229, Hôpital Pellegrin, Place Amélie Raba Léon, F-33076, Bordeaux, France

    Yves Cazals, Jean-Marie Aran & Renaud Charlet de Sauvage

Authors
  1. Yves Cazals
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  2. Jean-Marie Aran
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  3. Renaud Charlet de Sauvage
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Supported by grants from DGRST DN 80.7.0233 and INSERM 81.6.037

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Cazals, Y., Aran, JM. & Charlet de Sauvage, R. Artificial activation and degeneration of the cochlear nerve in guinea pigs. Arch Otorhinolaryngol 238, 1–8 (1983). https://doi.org/10.1007/BF00453735

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  • DOI: https://doi.org/10.1007/BF00453735

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