Summary
Rhabdomyoma is a rare tumor of skeletal muscle origin which can occur in different localizations. The head and neck region is a site of predilection for the adult type. Its absolutely benign behavior makes correct diagnosis crucial. In this study, a case of an extracardiac rhabdomyoma of the larynx was found to recur 12 years after initial treatment. Following its surgical removal, histology showed typical patterns of an adult type of rhabdomyoma with focal cross-striations. Immunocytochemically, all applied muscular markers were positive. Electron microscopy revealed muscular filaments with cross-striations and glycogen granules. These findings showed that immunocytochemistry plays an important role in differential diagnosis and the need for possible further treatment.
Similar content being viewed by others
References
Andersen CB, Elling F (1986) Adult rhabdomyoma of the oropharynx recurring three times within thirty-five years. Acta Pathol Microbiol Immunol Scand [A] 94:281–284
Batsakis JG, Manning JT (1986) Soft tissue tumors: unusual forms. Otolaryngol Clin North Am 19:659–683
Bondeson L, Andreasson L (1986) Aspiration cytology of adult rhabdomyoma. Acta Cytol 30:679–682
Bozic C (1986) Fetal rhabdomyoma of the parotid gland in an infant: histological, immunohistochemical and ultrastructural features. Pediatr Pathol 6:139–144
Cerasoli PT, Pirodda A, Caliceti U (1985) Rabdomioma di tipo adulto della regione faringo-laringea: presentazione di un caso clinico e studio immunoistochimico. Acta Otorhinol Ital 5:175–183
Coindre JM, Mascarel A de, Trojani M, Mascarel I de, Pages A (1988) Immunohistochemical study of rhabdomyosarcoma. Unexpected staining with S 100 protein and cytokeratin. J Pathol 155:127–132
Corio RL, Lewis DM (1979) Intraoral rhabdomyomas. Oral Surg 48:525–531
Di Sant' Agnese PA, Knowles DM (1980) Extracardiac rhabdomyoma: a clinicopathologic study and review of the literature. Cancer 46:780–789
Eeckhaut J van den, Fievez C, Remacle M, Coffyn MB, Marbaix E (1983) Rhabdomyome adulte du larynx. A propos d' un cas. Ann Otolaryngol 100:151–153
Eigenbrodt ML, Cunningham LF (1986) Fine needle aspiration cytology of a rhabdomyoma of the pharynx. Acta Cytol 30:528–532
Enzinger FM, Weiss SW (1983) Soft tissue tumors, 2nd edn. Mosby, St. Louis, pp 433–447
Gale N, Rott T, Kambic V (1984) Nasopharyngeal rhabdomyoma. Report of case (light and electron microscopic studies) and review of the literature. Pathol Res Pract 178:454–460
Gardner DG, Corio RL (1983) Multifocal adult rhabdomyoma. Oral Surg 56:76–77
Gardner DG, Corio RL (1983) Fetal rhabdomyoma of the tongue, with a discussion of the two histologic variants of this tumor. Oral Surg 56:293–300
Granich MS, Pilch BZ, Nadol JB, Dickersin R (1983) Fetal rhabdomyoma of the larynx. Arch Otolaryngol 109:821–826
Heffner DK (1983) Problems in pediatric otorhinolaryngic pathology. I. Sinonasal and nasopharyngeal tumors and masses with myxoid features. Int J Pediatr Otorhinolaryngol 5:77–91
Kleinsasser O (1987) Tumoren des Larynx und des Hypopharynx. Thieme, Stuttgart, pp 339–349
Konrad EA, Hübner G (1983) Rhabdomyoma of the eyebrow region: a light- and electron microscopic study of a recurrent rhabdomyoma of fetal type. Graefes Arch Clin Exp Ophthalmol 220:187–192
Konrad EA, Meister P, Hübner G (1982) Extracardiac rhabdomyoma. Report of different types with light microscopic and ultrastructural studies. Cancer 49:898–907
Lattes R (1982) Tumors of the soft tissues. Atlas of tumor pathology, 2nd series. Armed Forces Institute of Pathology, Washinton, pp 66–69
Leader M, Patel J, Collins M, Henry K (1987) Anti-alpha-1-antichymotrypsin staining of 194 sarcomas, 38 carcinomas, and 17 malignant melanomas. Its lack of specificity as a tumour marker. Am J Surg Pathol 11:133–139
Lehtonen E, Asikainen U, Badley RA (1982) Rhabdomyoma. Ultrastructural features and distribution of desmin, muscle type of intermediate filament protein. Acta Pathol Microbiol Immunol Scand [A] 90:125–129
Meuten DJ, Calderwood Mays MB, Dillman RC, Cooper BJ, Valentine BA, Kuhajda FP, Pass DA (1985) Canine laryngeal rhabdomyoma. Vet Pathol 22:533–539
Modlin B (1982) Rhabdomyoma of the larynx. Laryngoscope 92:580–582
Nolte E, Kleinsasser O (1982) Granularzelltumoren des Kehlkopfs. HNO 30:333–339
Painter MJ, Pang D, Ahdab-Barmada M, Bergman I (1984) Connatal brain tumors in patients with tuberous sclerosis. Neurosurgery 14:570–573
Pradhan SA, Rajpal RM, Shrikhande SS (1986) Extracardiac rhabdomyoma: a report of two cases. J Surg Oncol 33:69–71
Reid CO, Smith CJ (1985) Rhabdomyoma of the floor of the mouth: a new case and review of recently reported intraoral rhabdomyomas. Br J Oral Maxillofac Surg 23:284–291
Rosenman D, Gertner R, Fradis M, Podoshin L, Misslevitsch A, Boss JH (1986) Rhabdomyoma of the larynx. J Laryngol Otol 100:607–610
Schlosnagle MDC, Kratochvil FJ, Weathers DR, McConnel FMS, Campbell WG (1983) Intraoral multifocal adult rhabdomyoma. Arch Pathol Lab Med 107:638–642
Scrivner D, Meyer JS (1980) Multifocal recurrent adult rhabdomyoma. Cancer 46:790–795
Silseth C, Veress B, Bergström B (1982) A case of adult rhabdomyoma in the tonsillar region. A light and electron microscope study. Acta Pathol Microbiol Immunol Scand [A] 90:1–4
Simha M, Doctor V, Dalal S, Manghani DK, Dastur DK (1982) Postauricular fetal rhabdomyoma: light and electron microscopic study. Hum Pathol 13:673–677
Stewart CM, Watson RE, Eversole LR, Fischlschweiger W, Leider AS (1988) Oral granular cell tumors: a clinicopathologic and immunocytochemical study. Oral Surg 65:427–435
Warner TFCS, Goell W, Sundharadas M, Falk VS (1981) Adult rhabdomyoma. Arch Pathol Lab Med 105:608–611
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hamper, K., Renninghoff, J. & Schäfer, H. Rhabdomyoma of the larynx recurring after 12 years: immunocytochemistry and differential diagnosis. Arch Otorhinolaryngol 246, 222–226 (1989). https://doi.org/10.1007/BF00453667
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00453667