Summary
In order to overcome the disadvantages of the classic epior perineural nerve suture techniques, attempts have been made to secure nerve endings by a variety of measures, as exemplified by the use of artificial and biological glues. The use of a fibrinogenthrombin adhesive to seal nerve endings is an easy, time-saving method at surgery and provides excellent coaptation of the severed nerve fascicles with minimal iatrogenic trauma. However, the problem remains of excessive connective tissue proliferation at the junction site or of premature loss of tensile strenght before proper nerve healing occurs. The combination of the biological glue with the tubulization technique, associated with a fascicular and/or interfascicular nerve junction, may overcome the disadvantages associated with previous nerve repairs.
Similar content being viewed by others
References
Beck E, Ducken F, Vogel A, Ernst M (1962) Der Einfluß des Fibrinstabilisierenden Faktors (FSF) auf Funktion und Morphologie von Fibroblasten in vitro. Z Zellforsch 57:327–346
Becker CM, Gueuning CO, Graff GL (1984) Sutures of fibrin glue for divided rat nerves. J Reconst Microsurg 1:139–145
Berger A, Meissl G, Samii M (1970) Experimentelle Erfahrungen mit Kollagenfolien über nahtlose Nerven Anastomosen. Acta Neurochir 23:141–149
Boedts D, Bouckaert JI (1985) Nerve anastomosis: suturing and sealing. In: Portmann M (ed) Proceedings of the Fifth International Symposium on Facial Nerve, Bordeaux, 1984. Masson, New York, pp 523–526
Bruhn HD, Christophers E, Pohl J, Schoel G (1980) Regulation der Fibroblastenproliferation durch Fibrinogen (Fibrin, Fibronectin und Faktor XIII). In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. Schattauer, Stuttgart New York, pp 217–226
Chiu D, Janecka IP, Krizet T (1980) Autogenous vein graft as a conduit for nerve regeneration. Surg Forum 31:550–551
Colin W, Donoff RB (1984) Nerve regeneration through collagen tube. J Dent Res 63:987–993
Duspiva W, Blümel G, Haas-Denk S, Wriedt-Lübbe I (1977) Eine neue Methode der Anastomosierung durchtrennter peripherer Nerven. Langenbecks Arch Chir [Suppl] 289:100–104
Fisch U (1972) Die Verletzungen der Nervus Facialis bei laterobasalen Schädelfrakturen. Med Mitt Melsungen 46/116:165–175
Knoche H, Schmitt G (1976) Autoradiographische Untersuchungen über den Einfluß des Faktors XIII auf die Wundheilung im Tierexperiment. Arzneimittelforschung 26:547–551
Kuderna H (1981) Ergebnisse und Erfahrungen in der klinischen Anwendung des Fibrinklebers bei der Wiederherstellung durchtrennter peripherer Nerven. In: Cotte H, Martini AK (ed) Implante und Transplantate in der plastischen und Wiederherstellungschirurgie. Springer, Berlin Heidelberg New York, pp 96–100
Kuderna H, Dinges H, Redl H (1973) Nervenklebung. Dtsch Z Mund-Kiefer-Gesichts-Chir 3:32–35
Kuderna H, Dinges H, Redl H (1980) Die Fibrinklebung in der Mikrochirurgie der peripheren Nerven. Hefte Unfallheilkd 148:822–825
Matras H, Braun F, Lassman H, Ammerer HP, Mamoli B (1973) Plasma clot welding of nerves (experimental report). J Maxillofac Surg 1:236–247
Miehlke A (1973) Surgery of the facial nerve. Urban and Schwarzenberg, Munich/Saunders, Philadelphia
Millesi H (1968) Zum Problem der Überbrückung von defekten peripherer Nerven. Wien Med Wochenschr 118: 182–187
Millesi H (1977) Facial nerve suture. In: Fisch U (ed) Facial nerve surgery. Proceedings of the Third International Symposium on Facial Nerve Surgery. Zurich, 1976. Kugler Amstelveen, pp 209–215
Millesi H, Berger A, Meissl G (1972) Experimentelle Untersuchungen zur Heilung durchtrennter peripherer Nerven. Chir Plast 1: 174–206
Nomura S (1967) Observations on the operation method for the repair of the peripheral nerve injuries (in Japanese). Seikei Geka (Orthopaedic Surgery) 18:1242–1254. Quoted by Yamamoto and Fisch [24]
Rice DH, Berstein FD (1984) The use of autogenous vein for nerve grafting. Otolaryngol Head Neck Surg 92:410–412
Turowski G, Schaadt M, Berthels M, Diel G, Poliwoda H (1980) Unterschiedlicher Einfluß von Fibrinogen und Faktor XIII auf das Wachstum von Primärund Kulturfibroblasten. In: Schimpf K (Hrsg) Fibrinogen, Fibrin und Fibrinkleber. Schattauer, Stuttgart New York, pp 227–237
Vuursteen PJ (1985) Nerve repair and regeneration. In: Portmann M (ed) Proceedings of the Fifth International Symposium on Facial Nerve, Bordeaux, 1984. Masson, New York
Wriedt-Lübbe I, Kuderna H, Denk G, Schlag G, Blümel G (1976) Fibrinolyse-autographische Untersuchungen traumatisch durchtrennter Nerven vor der Rekonstruktion. Kongressbericht Oesterr Ges Chir, Salzburg
Yamamoto E, Fisch U (1974) Experiments on facial nerve suturing, ORL 36:193–204
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Boedts, D. A comparative experimental study on nerve repair. Arch Otorhinolaryngol 244, 1–6 (1987). https://doi.org/10.1007/BF00453481
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00453481