Skip to main content
Log in

Lipid peroxidation and superoxide dismutase activity in muscle and erythrocytes in adult muscular dystrophies and neurogenic atrophies

  • Published:
European archives of psychiatry and neurological sciences Aims and scope Submit manuscript

Summary

Lipid peroxidation (LP) and superoxide dismutase (SOD) activity were determined in erythrocytes and skeletal muscle obtained from patients with limb-girdle and facioscapulohumeral muscular dystrophies, neurogenic atrophies and from age-matched control subjects. Neither lipid peroxidation nor SOD activity in erythrocytes of patients differed from control values. SOD activity and LP in muscle specimens were also normal in types of neurogenic atrophy. Lipid peroxidation in the muscle from patients with adult types of muscular dystrophy had a tendency to be increased. The values were widely scattered, the highest being obtained in the older patients with long duration of disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Burri BJ, Chan SG, Berry AJ, Yarnell SK (1980) Blood levels of superoxide dismutase and glutathione peroxidase in Duchenne muscular dystrophy. Clin Chim Acta 105:249–255

    Google Scholar 

  • Concetti A, Massei P, Rotillo G, Bruneri M, Rachmilewitz EA (1976) Superoxide dismutase in red blood cells — method of assay and enzyme content in normal subjects and in patients with β-thalassemia (major and intermedia). J Lab Clin Med 87:1057–1064

    Google Scholar 

  • Del Maestro AF (1980) An approach to free radicals in medicine and biology. Acta Physiol Scand [Suppl] 492:153–168

    Google Scholar 

  • Hunter MIS, Brzeski MS, De Vane PJ (1981) Superoxide dismutase, glutathione peroxidase and thiobarbituric acid-reactive compounds in erythrocytes in Duchenne muscular dystrophy. Clin Chim Acta 115:93–98

    Google Scholar 

  • Kar NC, Pearson CM (1979) Catalase, superoxide dismutase, glutathione reductase and thiobarbituric acid-reactive products in normal and dystrophic human muscle. Clin Chim Acta 94:277–280

    Google Scholar 

  • Matkovics B, Lászó A, Szabó L (1982) A comparative study of superoxide dismutase, catalase and lipid-peroxidation in red blood cells from muscular dystrophy patients and normal controls. Clin Chim Acta 118:289–292

    Google Scholar 

  • Mechler F, Imre S, Diószeghy P (1984) Lipid peroxidation and superoxide dismutase activity in muscle and erythrocytes in Duchenne muscular dystrophy. J Neurol Sci 63:279–283

    Google Scholar 

  • Mengel CE, Kann HE Jr (1966) Effects of in vivo hyperoxia on erythrocytes, Part 3. In vivo peroxidation of erythrocyte lipid. J Clin Invest 45: 1150–1158

    Google Scholar 

  • Myllylä V, Kihlström M, Takala TES, Tolonen U, Salminen A, Vihko V (1986) Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular disease. Acta Neurol Scand 74:17–24

    Google Scholar 

  • Omaye ST, Tappel AL (1974) Glutathione peroxidase, glutathione reductase and thiobarbituric acid-reactive products in muscle of chickens and mice with genetic muscular dystrophy. Life Sci 15:137–145

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Diószeghy, P., Imre, S. & Mechler, F. Lipid peroxidation and superoxide dismutase activity in muscle and erythrocytes in adult muscular dystrophies and neurogenic atrophies. Eur Arch Psychiatr Neurol Sci 238, 175–177 (1989). https://doi.org/10.1007/BF00451007

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00451007

Key words

Navigation