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Stoffwechselprodukte von Mikroorganismen

154. Mitteilung. Nikkomycin, ein neuer Hemmstoff der Chitinsynthese bei Pilzen

Metabolic products of microorganisms

154. Nikkomycin, a new inhibitor of fungal chitin synthesis

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Abstract

From the fermentation broth of Streptomyces tendae Tü 901 a substance was isolated, which inhibits the growth of several fungi. The new antibiotic affects the chitchin biosynthesis. Its structure was identified by mass spectrometry of the products obtained after chemical degradation. Nikkomycin is a nucleoside-peptide antibiotic consisting of uracil, an amino hexuronic acid and a new amino acid containing a pyridin ring.

Zusammenfassung

Der Streptomycet Tü 901, Streptomyces tendae, bildet ein antifungisch wirkendes Nukleosid-Antibioticum, Nikkomycin. Als Angriffsort kommt die Chitinsynthese in Frage.

Mit Hilfe der Massenspektrometrie und des chemischen Abbaus konnten Uracil, eine Aminohexuronsäure und eine neue, einen Pyridinring enthaltende Aminosäure nachgewiesen werden.

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Author notes

  1. H. Höhne

    Present address: Pharma Mikrobiologie, Farbwerke Hoechst AG, D-6000, Frankfurt a. M. 80

  2. W. A. König

    Present address: Institut for Organische Chemie und Biochemie der Universität, Martin-Luther-King-Platz, D-2000, Hamburg 13

Authors and Affiliations

  1. Lehrstuhl für Mikrobiologie I, Institut für Biologie II, Auf der Morgenstelle 28, D-7400, Tübingen, Bundesrepublik Deutschland

    U. Dähn, H. Hagenmaier, H. Höhne, W. A. König, G. Wolf & H. Zähner

  2. Institut für Organische Chemie der Universität, Auf der Morgenstelle 28, D-7400, Tübingen, Bundesrepublik Deutschland

    U. Dähn, H. Hagenmaier, H. Höhne, W. A. König, G. Wolf & H. Zähner

Authors
  1. U. Dähn
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  2. H. Hagenmaier
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  3. H. Höhne
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  4. W. A. König
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  5. G. Wolf
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  6. H. Zähner
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Additional information

153. Mitteilung: G. Wolf, J. Wörth, H. Achenbach: Untersuchungen der Pigmente aus Streptomyces michiganesis. Arch. Microbiol. 106, 245–249 (1975)

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Dähn, U., Hagenmaier, H., Höhne, H. et al. Stoffwechselprodukte von Mikroorganismen. Arch. Microbiol. 107, 143–160 (1976). https://doi.org/10.1007/BF00446834

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  • DOI: https://doi.org/10.1007/BF00446834

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