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Genetic control of ethanol action on the central nervous system

An EEG Study in Twins

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Summary

The purpose of the investigation is to clarify the genetic contribution to the interindividual variability of ethanol action on the central nervous system. The 52 adult male healthy twin pairs (26 MZ, 26 DZ) got 1.2 ml/kg ethanol p.o. under standardized conditions; furthermore, 13 non-twin subjects were repeatedly subjected to the same procedure in order to test the intraindividual variability. The EEG was recorded before and 60, 120, 180, and 240 min after alcohol intake. The EEGs were off-line analyzed by means of a computer program for time domain analysis. As was already known, on the average alcohol led to a better synchronisation of the EEG, i.e., the number of beta-waves decreased whereas the number of alpha- and theta-waves increased. The extent of the alcohol effect on the EEG varied enormously between individuals; however, the EEGs of MZ twins proved to react indentically to alcohol loading, whereas the EEGs of DZ twins became more dissimilar during the course of the experiment. The low-voltage EEG presumably is resistant to alcohol; furthermore, it is supposed that there exists a special beta-prone EEG-type which is also genetic in origin. The identical EEG reaction of MZ twins to alcohol loading could not be attributed to more similar blood alcohol concentrations. It is hypothesized that the differences in the extent of the alcohol effect on the EEG between individuals might reflect differences in the sensitivity of the ascending reticular activating system. In the literature it has frequently been reported that alcoholics have preferentially brain wave patterns which are poorly synchronized. These findings are discussed in the light of the present results.

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References

  • Amark, C.: A study in alcoholism: clinical, social-psychiatric and genetic investigations. Acta Psychiat. Neurol. Scand., Suppl. 70 (1951)

  • Begleiter, H., Platz, A.: The effects of alcohol on the central nervous system in humans. In: The biology of alcoholism, B. Kissin and H. Begleiter, eds, Vol. 2. New York-London 1972

  • Bente, D.: Differentielle und generelle Wirkungen psychotroper Pharmaka auf das menschliche EEG. Psychopharmacology, Sexual Disorders and Drug Abuse, Ban, T. A. et al., eds., Proc. of the Symp. at the VIII Congr. of the CINP Copenhagen, pp. 149–156. Amsterdam: North-Holland 1973

    Google Scholar 

  • Bente, D., Matejcek, M., Penning, J., Schenk, G.: Spektralanalytische Untersuchungen zur Wirkung von Etifoxin auf das menschliche EEG. Arzneim.-Forsch. 25, 944–947 (1975)

    Google Scholar 

  • Borenstein, P., Cujo, P.: Effects of major tranquilizers on the resting EEG. In: Psychotropic drugs and the human EEG, T. M. Itil, ed. Basel: Karger 1974

    Google Scholar 

  • Brown, B. B.: New mind, new body: new directions for the mind. London: Hodder and Stoughton 1975

    Google Scholar 

  • Brugger, C.: Familienuntersuchungen bei chronischen Alkoholdelikern. Zschr. ges. Neurol. Psychiat. 151, 103–129 (1934a)

    Google Scholar 

  • Brugger, C.: Familienuntersuchungen bei Alkoholdeliranten. Zschr. ges. Neurol. Psychiat. 151, 740–788 (1934b)

    Google Scholar 

  • Caspers, H.: Die Beeinflussung der corticalen Krampferregbarkeit durch das aufsteigende Reticulärsystem des Hirnstammes. I. Reizwirkungen. Zschr. ges. exp. Med. 129, 128–144 (1957)

    Google Scholar 

  • Caspers, H.: Die Beeinflussung der corticalen Krampferregbarkeit durch das aufsteigende Reticulärsystem des Hirnstammes. II. Narkosewirkungen. Zschr. ges. exp. Med. 129, 582–600 (1958)

    Google Scholar 

  • Caspers, H., Abele, G.: Hirnelektrische Untersuchungen zur Frage der quantitativen Beziehungen zwischen Blutalkoholgehalt und Alkoholeffekt. Dtsch. Zschr. ges. gerichtl. Med. 45, 492–509 (1956)

    Google Scholar 

  • Creutzfeldt, O. (ed): Electrical activity from the neuron to the EEG and EMG. In: Handbook of electroencephalography and clinical neurophysiology, A. Rémond (editor in chief), Vol. 2. Amsterdam: Elsevier 1974

    Google Scholar 

  • Davis, P. A., Gibbs, F. A., Davis, H., Jetter, W. W., Trowbridge, L. S.: The effects of alcohol upon the electroencephalogram (brain waves). Q. J. Stud. Alcohol. 1, 626–637 (1941)

    Google Scholar 

  • Docter, R. F., Naitoh, P., Smith, J. C.: Electroencephalographic changes and vigilance behavior during experimentally induced intoxication with alcoholic subjects. Psychosomat. Med. 28, 605–615 (1966)

    Google Scholar 

  • Elbel, H., Schleyer, F.: Blutalkohol. Stuttgart: Thieme 1956

    Google Scholar 

  • Engel, G. L., Rosenbaum, M.: Delirium III. The electroencephalographic changes associated with acute alcoholic intoxication. Arch. Neurol. Psychiat. 53, 44–50 (1945)

    Google Scholar 

  • Engel, G. L., Webb, J. P., Ferris, E. B.: Quantitative electroencephalographic studies of anoxia in humans: comparison with acute alcoholic intoxication and hypoglycemia. J. Clin. Invest. 24, 691–697 (1945)

    Google Scholar 

  • Essig, C. F., Fraser, H. F.: Electroencephalographic changes in man during use and withdrawal of barbiturates in moderate dosage. EEG Clin. Neurophysiol. 10, 649–656 (1958)

    Google Scholar 

  • Ewing, J. A., Rouse, B. A., Pellizzari, E. D.: Alcohol sensitivity and ethnic background. Amer. J. Psychiat. 131, 206–210 (1974)

    Google Scholar 

  • Eysenck, H. J.: The biological basis of personality. Springfield, Ill.: C. C. Thomas 1970

    Google Scholar 

  • Fink, M.: EEG profiles and bioavailability measures of psychoactive drugs. In: Psychotropic drugs and the human EEG, T. M. Itil, ed. Basel: Karger 1974

    Google Scholar 

  • Funderburk, W. H.: Electroencephalographic studies in chronic alcoholism. Electroenceph. Clin. Neurophysiol. 1, 369–370 (1949)

    Google Scholar 

  • Funkhouser, J. B., Nagler, B., Walke, N. D.: The electroencephalogram of chronic alcoholism. South. Med. J. 46, 423–428 (1953)

    Google Scholar 

  • Gibbs, F. A., Gibbs, E. L., Lennox, W. G.: The effect on the electroencephalogram of certain drugs which influence nervous activity. Arch. Int. Med. 60, 154–166 (1937)

    Google Scholar 

  • Goldstein, L.: Time domain analysis of the EEG. The integrative method. In: Computerized EEG analysis, G. Dolce and H. Künkel, eds. Stuttgart: Fischer 1975

    Google Scholar 

  • Goodwin, D. W., Schulsinger, F., Hermansen, L., Guze, S. B., Winokur, G.: Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch. Gen. Psychiat. 28, 238–243 (1973)

    Google Scholar 

  • Goodwin, D. W., Schulsinger, F., Møller, N., Hermansen, L., winokur, G., Guze, S.: Drinking problems in adopted and nonadopted sons of alcoholics. Arch. Gen. Psychiat. 31, 164–169 (1974)

    Google Scholar 

  • Gregory, I.: Family data concerning the hypothesis of hereditary predisposition toward alcoholism. J. Ment. Sci. 106, 1068–1072 (1960)

    Google Scholar 

  • Grüner, O., Ludwig, O.: Konstitution und Alkoholwirkung. Ärztl. Forsch. 14, 303–311 (1960)

    Google Scholar 

  • Hedenström, I. v., Schmidt, O.: Electroencephalographische Untersuchungen nach Alkoholgabe. Dtsch. Zschr. gerichtl. Med. 40, 234–251 (1951)

    Google Scholar 

  • Himwich, H. E., Diperri, R., Dravid, A., Schweigerdt, A.: Comparative susceptibility to alcohol of the cortical area and midbrain reticular formation of the cat. Psychosomat. Med. 28, 458–463 (1966)

    Google Scholar 

  • Holmberg, G., Martens, S.: Electroencephalographic changes in man correlated with blood alcohol concentration and some other conditions following standard ingestion of alcohol. Q. J. Stud. Alcohol. 16, 411–424 (1955)

    Google Scholar 

  • Horsey, W. J., Akert, K.: Influence of ethyl alcohol on the electroencephalogram of the cat. Electroenceph. Clin. Neurophysiol. 5, 318 (1953)

    Google Scholar 

  • Itil, T. M.: Quantitative pharmaco-electroencephalography. Use of computerized cerebral biopotentials in psychotropic drug research. In: Psychotropic drugs and the human EEG, T. M. Itil, ed. Basel: Karger 1974

    Google Scholar 

  • Jones, F. W., Holmes, D. S.: Alcoholism, alpha production, and biofeedback. J. Consult. Clin. Psychol. 44, 224–228 (1976)

    Google Scholar 

  • Jones, B. M.: Cognitive performance of introverts and extraverts following acute alcohol ingestion. Br. J. Psychol. 65, 35–42 (1974)

    Google Scholar 

  • Jovanovié, U. J.: Schlaf und Traum. Stuttgart: Fischer 1974

    Google Scholar 

  • Kaij, L.: Alcoholism in twins. Stockholm: Almqvist and Wiksell 1960

    Google Scholar 

  • Kopun, M., Propping, P.: The kinetics of ethanol absorption and elimination in twins supplemented by repetitive experiments in single subjects. Eur. J. Clin. Pharmacol. (in press)

  • Legewie, H., Probst, W.: On-line analysis of EEG with a small computer (period-amplitude analysis). Electroenceph. Clin. Neurophysiol. 27, 533–535 (1969)

    Google Scholar 

  • Lennox, W. G., Gibbs, F. A., Gibbs, E. L.: The brain wave pattern, an hereditary trait.Evidence from 74 “normal” pairs of twins. J. Hered. 36, 233–243 (1945)

    Google Scholar 

  • Lienert, G. A.: Verteilungsfreie Methoden in der Biostatistik. Meisenheim am Glan: Hain 1973

    Google Scholar 

  • Little, S. C., McAvoy, M.: Electroencephalographic studies in alcoholism. Q. J. Stud. Alcohol. 13, 9–15 (1952)

    Google Scholar 

  • McClearn, G. E.: Genetics as a tool in alcohol research. Ann N.Y. Acad. Sci. 197, 26–31 (1972)

    Google Scholar 

  • Mendlewicz, J.: Genetics and psychopharmacology. Basel: Karger 1975

    Google Scholar 

  • Munkelt, P., Lienert, G. A.: Blutalkoholspiegel und psychophysische Konstitution. Arzneim.-Forsch. 14, 573–575 (1964)

    Google Scholar 

  • Naitoh, P.: The value of electroencephalography in alcoholism. Ann. N.Y. Acad. Sci. 215, 303–320 (1973)

    Google Scholar 

  • Newman, W.: The effect of alcohol on the encephalogram. Stanford Med. Bull. 17, 55–60 (1959)

    Google Scholar 

  • Partanen, J., Bruun, K., Markkanen, T.: Inheritance of drinking behaviour—a study on intelligence, personality and use of alcohol of adult twins. Helsinki: The Finnish Foundation for Alcohol Studies, Publication, No. 14, 1966

    Google Scholar 

  • Pertin, R. G., Hockman, C. H., Kalant, H., Livingston, K. E.: Acute effects of ethanol on spontaneous and auditory evoked electrical activity in cat brain. Electroenceph. Clin. Neurophysiol. 36, 19–31 (1974)

    Google Scholar 

  • Person, R. J., Gunn, C. G.: Effects of ethanol on recruiting, augmenting and reticular activation response thresholds. Q. J. Stud. Alcohol. 35, 987–1002 (1974)

    Google Scholar 

  • Propping, P.: Psycho-physiological performance in normal twins and in a pair of identical twins with essential tremor which is suppressed by alcohol. Submitted to Hum. Genet.

  • Propping, P., Kopun, M.: Pharmacogenetic aspects of psychoactive drugs: facts and fancy. Hum. Genet. 20, 291–320 (1973)

    Google Scholar 

  • Reed, T. E., Kalant, H., Gibbins, R. J., Kapur, B. M., Rankin, J. G.: Racial differences in rates of alcohol and acetaldehyde metabolism. Amer. J. Hum. Genet. 27, 75A (1975)

  • Rodgers, D. A.: Factors underlying differences in alcohol prefenence of inbred strains of mice. In: The biology of alcoholism, B. Kissin and H. Begleiter, eds. New York-London: Plenum 1972

    Google Scholar 

  • Schuckit, M. A.: Family history and half-sibling research in alcoholism. Ann. N. Y. Acad. Sci. 197, 121–125 (1972)

    Google Scholar 

  • Schuckit, M. A., Goodwin, D. W., Winokur, G.: A study of alcoholism in half siblings. Amer. J. Psychiat. 128, 122–126 (1972)

    Google Scholar 

  • Smith, J., Probst, W., Schuh, H.: A computer analysis of the aperiodic amplitude-interval parameters of the electroencephalogram. EDV in Med. u. Biol. 1, 8–15 (1973)

    Google Scholar 

  • Sperry, R. W.: Lateral specialization in the surgically separated hemispheres. In: The Neurosciences, Third Study Program, F. O. Schmitt and F. G. Worden, eds. Cambridge, Mass.-London: MIT Press 1974

    Google Scholar 

  • Stamatoyannopoulos, G., Chen, S.-H., Fukui, M.: Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity. Amer. J. Hum. Genet. 27, 789–796 (1975)

    Google Scholar 

  • Travis, T. A., Kondo, C. Y., Knott, J. R.: Subjective aspects of alpha enhancement. Br. J. Psychiat. 127, 122–126 (1975)

    Google Scholar 

  • Vesell, E. S.: Advances in pharmacogenetics. Progr. Med. Genet. 9, 291–367 (1973)

    Google Scholar 

  • Vogel, F.: Über die Erblichkeit des normalen Elektroencephalogramms. Stuttgart: Thieme 1958

    Google Scholar 

  • Vogel, F.: The genetic basis of the normal human electroencephalogram (EEG). Hum. Genet. 10, 91–114 (1970)

    Google Scholar 

  • Wld. Hlth. Org. techn. Rep. Ser. No. 524: Pharmacogenetics 1973

  • Winokur, G., Clayton, P. J.: Family history studies: IV. Comparison of male and female alcoholics. Q. J. Stud. Alchol. 29, 885–891 (1968)

    Google Scholar 

  • Wolff, P. H.: Ethnic differences in alcohol sensivity. Science 175, 449–450 (1972)

    Google Scholar 

  • Wolff, P. H.: Vasomotor sensitivity to alcohol in diverse mongoloid populations. Amer. J. Hum. Genet. 25, 193–199 (1973)

    Google Scholar 

  • Young, J. P., Lader, M. H., Fenton, G. W.: A twin study of the genetic influences on the electroencephalogram. J. Med. Genet. 9, 13–16 (1972)

    Google Scholar 

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  1. Institut für Anthropologie und Humangenetik der Universität Heidelberg, Neuenheimer Feld 328, D-6900, Heidelberg, Federal Republic of Germany

    P. Propping

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Propping, P. Genetic control of ethanol action on the central nervous system. Hum Genet 35, 309–334 (1977). https://doi.org/10.1007/BF00446623

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