Abstract
The recombinant inbred (RI) set of strains, AXB and BXA, derived from C57BL/6J and A/J, originally constructed and maintained at the University of California/San Diego, have been imported into The Jackson Laboratory and are now in the 29th to 59th generation of brother-sister matings. Genetic quality control testing with 45 proviral and 11 biochemical markers previously typed in this RI set indicated that five strains had been genetically contaminated sometime in the past, so these strains have been discarded. The correct and complete strain distribution patterns for 56 genetic markers are reported for the remaining RI strain set, which consists of 31 living strains and 8 extinct strains for which DNA is available. Two additional strains, AXB 12 and BXA 17, are living and may be added to the set pending further tests of genetic purity. The progenitors of this RI set differ in susceptibility to 27 infectious diseases as well as atherosclerosis, obesity, diabetes, cancer, cleft palate, and hydrocephalus. Thus, the AXB and BXA set of RI strains will be useful in the genetic analysis of several complex diseases.
Similar content being viewed by others
References
Ali-Khan, Z.: Host-parasite relationship in echinococcosis. I. Parasite biomass and antibody response in three strains of inbred mice against graded doses of Echinococcus multilocularis cysts. J Parasitol 60: 231–235, 1974.
Bailey, D.W.: Recombinant inbred strains and bilineal congenic strains. In H.L. Foster, J.D. Small, and J.G. Fox (eds.); The Mouse in Biomedical Research: History, Genetics and Wild Mice, pp. 223–239, Academic Press, New York, 1981.
Behin, R., Manuel, J., and Sordat, B.: Leishmania tropica: pathogenicity and in vitro macrophage function in strains of inbred mice. Exp Parasitol 48: 81–91, 1979.
Blatt, C., Harper, M.E., Franchini, G., Nesbitt, M.N., and Simon, M.I.: Chromosomal mapping of murine c-fes and c-srd genes. Mol Cell Biol 4: 978–981, 1984.
Brown, I.N., Glynn, A.A., and Plant, J.: Inbred mouse strains resistance to Micobacterium lepraemurium follows the Ity/Lsh pattern. Immunology 47: 149–156, 1982.
Cheers, C. and McKenzie, I.F.: Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19: 755–767, 1978.
Chesbro, B. and Wehrly, K.: Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci USA 76: 425–429, 1979.
Chick, E.W. and Roberts, G.D.: The varying susceptibility of different genetic strains of laboratory mice to Histoplasma capsulatum. Mycopathol Mycol appl 52: 251–253, 1974.
Colley, D.G. and Freeman, G.L., Jr.: Differences in adult Schistosoma mansoni worm burden requirements for the establishment of resistance to reinfection in inbred mice. II. C57BL/KsJ, SWR/J, SJL/J, BALB/cAnN, DBA/2N, A/J, B10.A(3R), and B10.A(5R) mice. Am J Trop Med Hyg 32: 543–549, 1983.
Debre, P., Gisselbrecht, S., Boyer, B., and Levy, J.P.: Controle genetiques des leucemies murines induites par le virus de Moloney. Bull Cancer (Paris) 69: 178–187, 1982.
DeLorenzo, R.J. and Ruddle, F.H.: Genetic control of two electrophoretic variants of glucose phosphate isomerase in the mouse (Mus musculus). Biochem Genet 3: 151–162, 1969.
Dietrich, W., Katz, H., Lincoln, S.E., Shin, H.-S., Friedman, J., Dracopoli, N., and Lander, E.S.: A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131: 423–447, 1992.
Eicher, E., Stearn, R.H., Womack, J.E., Davisson, M.T., Roderick, T.H., and Reynolds, S.C.: Evolution of mammalian carbonic anhydrase loci by tandem duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet 14: 651–660, 1976.
Fanning, M.M. and Kazura, J.W.: Genetic association of murine susceptibility to Brugia malayi microfilaemia. Parasite Immunol 5: 305–316, 1983.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic analysis of endogenous xenotropic murine leukemia viruses: association with two common mouse mutations and the viral restriction locus Fv-1. J Virol 63: 1763–1774, 1989a.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice. J Virol 63: 3810–3821, 1989b.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M.: A linkage map of endogenous murine leukemia proviruses. Genetics 121: 221–236, 1990.
Frankel, W.N., Lee, B.K., Stoye, J.P., Coffin, J.M., and Eicher, E.M.: Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/BINJ and SM/J inbred strains. Mammalian Genome 2: 110–122, 1992.
Gorelik, E. and Herbermann, R.B.: Susceptibility of various strains of mice to urethan-induced lung tumors and depressed natural killer cell activity. J Natl Cancer Inst 67: 1317–1322, 1981.
Groves, M.G. and Osterman, J.V.: Host defenses in experimental scrub typhus: genetics of natural resistance to infection. Infect Immun 19: 583–588, 1978.
Hector, R.F., Domer, J., and Carrow, E.W.: Immune response to Candida albicans in genetically distinct Mice. Infect Immun 38: 1020–1028, 1982.
Hirst, R.G. and Wallace, M.E.: Inherited resistance to Corynebacterium kutscheri in mice. Infect Immun 14: 475–482, 1976.
Hutton, J.J., Linkage analysis using biochemical variants in mice. I. Linkage of the hemoglobin Beta-chain and glucose phosphate isomerase loci. Biochem Genet 3: 507–515, 1969.
Hutton, J.J. and Roderick, T.H.: Linkage analysis using biochemical variants in mice. III. Linkage relationships of eleven biochemical markers. Biochem Genet 4: 339–350, 1970.
Jenkins, N.A., Copeland, N.G., Taylor, B.A., and Lee, B.K.: Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol 43: 26–36, 1982.
Johnson, K.R.: Improved oligonucleotide labeling and hybridization assay for endogenous nonecotropic murine leukemia proviruses. Mammalian Genome 1: 260–262, 1991.
Klesius, P.H. and Hinds, S.E.: Strain-dependent differences in murine susceptibility to coccidia. Infect Immun 26: 1111–1115, 1979.
Landolfo, S., Martinotti, M.G., Martinetto, P., Forni, G., and Rabagliati, A.M.: Trichomonas vaginalis: dependence of resistance among different mouse strains upon the non-H-2 gene haplotype, sex, and age of recipient hosts. Exp Parasitol 52: 312–318, 1981.
Le Prevost, C., Virelizier, J.L., and Dupuy, J.M.: Immunopathology of mouse hepatitis virus type 3 infection. III. Clinical and virologic observation of a persistent viral infection. J Immunol 115: 640–643, 1975.
Levitt, R.C. and Mitzner, W.: Autosomal recessive inheritance of airway hyperactivity to 5-hydroxytryptamine. J Appl Physiol 67: 1125–1132, 1989.
Levy-LeBlond, E., Oth, D., and Dupuy, J.M.: Genetic study of mouse sensitivity to MHV3 infection: influence of the H-2 complex. J Immunol 122: 1359–1362, 1979.
Lewis, W.H.P. and Truslove, G.M.: Electrophoretic heterogeneity of mouse erythrocyte peptidase. Biochem Genet 3: 493–498, 1969.
Lilly, F. and Pincus, T.: Genetic control of murine viral leukemogenesis. Adv Cancer Res 17: 231–277, 1973.
Liu, S.L. and Erickson, R.P.: Genetic differences among the A/JxC57BL/6J recombinant inbred mouse lines and their degree of association with glucocorticoid-induced cleft palate. Genetics 113: 745–754, 1986.
Lopez, C.: Genetics of natural resistance to herpesvirus infections in mice. Nature 258: 152–153, 1975.
Lovell, D.P. and Erickson, R.P.: Genetic variation in the shape of the mouse mandible and its relationship to glucocorticoid-induced cleft palate analysed by using recombinant inbred lines. Genetics 113: 755–764, 1986.
Lusis, A.J., Taylor, B.A., Quon, D., Zollman, S., and LeBoeuf, R.C.: Genetic factors controlling structure and expression of apolipoproteins B and E in mice. J Biol Chem 262: 7594–7606, 1987.
Malkinson, A.M., Nesbitt, M.N., and Skamene, E.: Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model. J Natl Cancer Inst 75: 971–974, 1985.
Manly, K.F. and Elliott, R.W.: RI Manager, a microcomputer program for analysis of data from recombinant inbred strains. Mammalian Genome 1: 123–126, 1991.
Mattano, S.S., Erickson, R.P., Nesbitt, M.N., and Weber, W.W.: Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase. J Hered 79: 430–433, 1988.
Messer, A., Maskin, P., Plumkin, J., Coffin, J.M., and Frankel, W.F.: mapping of the motor neuron degeneration (Mnd) gene, a mouse model of Amyotrophic Lateral Sclerosis (ALS). Genomics 18, in press, 1992.
Mitchell, L.A. and Pearson, T.W.: Antibody responses induced by immunization of inbred mice susceptible and resistant to African trypanosomes. Infect Immun 40: 894–902, 1983.
Mitchell, G.F., Goding, J.W., and Rickard, M.D.: Studies on immune responses to larval cestodes in mice. Increased susceptibility of certain mouse strains and hypothymic mice to Taenia taeniaeformis and analysis of passive transfer of resistance with serum. Aust J Exp Biol Med Sci 55: 165–186, 1977.
Mobraaten, L.E.: The Jackson Laboratory genetics stocks resource repository. In G. Zeilmaker (ed.), Frozen Storage of Laboratory Animals, pp. 165–177, Gustav Fischer, Stuttgart, 1981.
Mobraaten, L.E.: Mouse embryo cryobanking. J In Vitro Fert Embryo Trans 3: 28–32, 1986.
Mock, B., Krall, M., Blackwell, J., O'Brien, A., Schurr, E., Gros, P., Skamene, E., and Potter, M.: A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus. Genomics 7: 57–64, 1990.
Mock, B., Neumann, P.E., Eppig, J.T., and Huppi, K.: Mouse chromosome 15. Mammalian Genome 1 (Suppl): S241-S268, 1991.
Morrison, W.I. and Murray, M.: Trypanosoma congolense: inheritance of susceptibility to infection in inbred strains of mice. Exp Parasitol 48: 364–374, 1979.
Nadeau, J.H., Ceci, J.D., and Cox, R.: Mouse chromosome 14. Mammalian Genome 1 (Suppl): S221-S240, 1991.
Nesbitt, M.N. and Skamene, E.: Recombinant inbred mouse strains derived from A/J and C57BL/6J: a tool for the study of genetic mechanisms in host resistance to infection and malignancy. J Leukocyte Biol 36: 357–364, 1984.
Nesbitt, M.N., Pugh, S.L., and Paigen, B.P.: Strain distribution pattern of thrrteen genetic loci in the AXB and BXA recombinant inbred set. Mouse Genome 88: 113, 1990.
Neumann, P.E.: Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem. Genetics 126: 277–284, 1990.
Niederkorn, J.Y., Shadduck, J.A., and Schmidt, E.C.: Susceptibility of selected inbred strains of mice to Encephalitozoon cuniculi. J Infect Dis 144: 249–253, 1981.
Paigen, B., Nesbitt, M.N., Mitchell, D., Albee, D., and LeBoeuf, R.C.: Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Genetics 122: 163–168, 1989.
Pennington, J.E.: Influence of genetic factors on natural resistance of mice to Pseudomonas aeruginosa. J Infect Dis 139: 386–400, 1979.
Philips, R.J.S.: The linkage of congenital hydrocephalus in the house mouse. J Hered 47: 302–304, 1956.
Plant, J. and Glynn, A.A.: Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis 133: 72–78, 1976.
Popp, R.A. and Popp, D.M.: Inheritance of serum esterases having different electrophoretic patterns—among inbred strains of mice. J Hered 53: 111–114, 1962.
Prehn, L.M. and Lawler, E.M.: Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen. Science 204: 309–310, 1979.
Roderick, T.H., Hutton, J.J., and Ruddle, F.H.: Linkage of Esterase-3 and Rex on linkage group VII of the mouse. J Hered 61: 278–279, 1970.
Sambrook, J., Fritsch, E.F., and Maniatis, T.: Molecular Cloning: A Laboratory Manual, pp. 11–34, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.
Seldin, M.F., Morse, H.C., LeBoeuf, R.C., and Steinberg, A.D.: Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q. Genomics 2: 48–56, 1988.
Shiroshi, T., Sagai, T., and Moriwaki, K.: A simplified micromethod for cytotoxicity testing using a flat-type titration plate for the detection of H-2 antigens. Microbiol Immunol 25: 1327–1334, 1981.
Shows, T.B., Chapman, V.M., and Ruddle, F.H.: Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse. Biochem Genet 4: 707–718, 1970.
Silver, J. and Buckler, C.E.: Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses. Proc Natl Acad Sci USA 83: 1423–1427, 1986.
Stevenson, M.M., Lyanga, J.J., and Skamene, E.: Murine malaria: genetic control of resistance to Plasmodium chabaudi. Infect Immun 38: 80–88, 1982.
Stevenson, M.M., Nesbitt, M.N., and Skamene, E.: Chromosomal location of the gene determining resistance to Plasmodium chabaudi AS. Curr Top Microbiol Immunol 137: 325–328, 1988.
Stoye, J.P. and Coffin, J.M.: Polymorphism of murine endogenous proviruses revealed by using virus-class-specific oligonucleotide probes. J Virol 62: 168–175, 1988.
Stoye, J., Moroni, C., and Coffin, J.: Virological events leading to spontaneous AKR thymomas. J Virol 65: 1273–1285, 1991.
Sundberg, J.P., Woolcott, B.L., Cunliffe-Beamer, T., Brown, K.S., and Bronson, R.: Spontaneous hydrocephalus in inbred strains of mice. In Jax Notes, 1991.
Surwit, R.S., Kuhn, C.M., Cochrane, C., McCubbin, J.A., and Feinglos, M.N.: Dtet-induced type II diabetes in C57BL/6J mice. Diabetes 37: 1163–1167, 1988.
Surwit, R.S., Seldin, M.F., Kuhn, C.M., Cochrane, C., and Feinglos, M.N.: Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. Diabetes 40: 82–87, 1991.
Taylor, B.A.: Recombinant inbred strains: use in gene mapping. In H.C.I. Morse (ed.); Orgins of Inbred Mice, pp. 423–438, Academic Press, New York, 1978.
Taylor, B.A.: Recombinant inbred strains. In M.F. Lyon and A.G. Searle (eds.); Genetic Variants and Strains of the Laboratory Mouse, pp. 773–796, Oxford University Press, Oxford, 1989.
Taylor, B.A. and Rowe, L.: Genes for serum amyloid A proteins map to chromosome 7 in the mouse. Mol Gen Genet 195: 491–499, 1984.
Thaete, L.G., Nesbitt, M.N., and Malkinson, A.M.: Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes. Cancer Lett 61: 15–20, 1991.
Trischmann, T.M. and Bloom, B.R.: Genetics of murine resistance to Trypanosoma cruzi. Infect Immun 36: 844–846, 1982.
Wilcox, F.H., Hirschhorn, L., Taylor, B.A., Womack, J.E., and Roderick, T.H.: Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganeserequiring isozyme. Biochem Genet 17: 1093–1107, 1979.
Youmans, G.P. and Youmans, A.S.: Response of vaccinated and nonvaccinated syngeneic C57BL-6 mice to infection with Mycobacterium tuberculosis. Infect Immun 6: 748–754, 1972.
Youngblood, G.L., Nesbitt, M.N., and Payne, A.H.: The structural genes encoding P450scc and P450arom are closely linked on mouse chromosome 9. Endocrinology 125: 2784–2786, 1989.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marshall, J.D., Mu, JL., Cheah, YC. et al. The AXB and BXA set of recombinant inbred mouse strains. Mammalian Genome 3, 669–680 (1992). https://doi.org/10.1007/BF00444361
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00444361