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Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus

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Abstract

Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%–40%), the mean fall was 24% (P<0.005). Though none of the infants showed signs of impaired cerebral function during or following the injections, the results do not indicate whether or not the use of indomethacin is a potential hazard.

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Abbreviations

PDA:

patent ductus arteriosus

CBF:

cerebral blood flow

PaCO2 :

arterial carbon dioxide tension

MAP:

mean arterial blood pressure

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Authors and Affiliations

  1. Department of Neonatology, State University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej, DK-2100, Copenhagen Ø, Denmark

    O. Pryds, G. Greisen & K. H. Johansen

Authors
  1. O. Pryds
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  2. G. Greisen
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  3. K. H. Johansen
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Pryds, O., Greisen, G. & Johansen, K.H. Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus. Eur J Pediatr 147, 315–316 (1988). https://doi.org/10.1007/BF00442705

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  • DOI: https://doi.org/10.1007/BF00442705

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