Abstract
Compensatory growth in 27 undiseased congenital solitary kidneys and in 31 solitary kidneys in patients with Wilms tumour was monitored in long-term follow-up studies by ultrasound volume biometry. In congenital solitary kidneys hypertrophy was not detectable at the time of birth. Parenchymal mass increase achieved 188% of the volume of a healthy kidney within at least 4 years of life and afterwards paralleled the physiological growth documented in healthy kidney pairs. Disease-free kidneys in Wilms tumour patients all developed a similar 180% volume augmentation within 2–4 years after nephrectomy, irrespective of the chosen mode of radiation and single or tripte chemotherapy. The age of the patient at onset of surgical and concomitant conservative therapy determined slight differences in kinetics but not in degree of compensatory growth.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- ACD:
-
actinomycin-D
- VCR:
-
vincristin
- ADM:
-
adriamycin
References
Andersen MJF, Mogensen CE (1973) Relationship between renal size and function in normal subjects. Acta Radiol [Diagn] 14:209–214
Aperia A, Broberger O, Wilton P (1978) Renal functional adaption in the remnant kidney in patients with renal agenesis and in patients nephrectomized in childhood. Acta Paediatr Scand 67: 611–615
Cassady JR, Lebowitz RL, Jaffe N, Hoffmann A (1981) Effect of low dose irradiation on renal enlargement in children following nephrectomy for Wilms tumour. Acta Radiol [Oncol] 20:5–8
Dinkel E, Ertel M, Dittrich M, Peters H, Berres M, Schulte-Wissermann H (1985) Kidney size in childhood: sonographical growth charts for kidney length and volume. Pediatr Radiol 15:38–43
Donaldson SS, Moskowitz PS, Canty EL, Efron B (1978) Radiation-induced inhibition of compensatory renal growth in the weanling mouse kidney. Radiology 128:491–495
Effmann EL, Ablow RC, Siegel NJ (1977) Renal growth. Radiol Clin North Am 15:3–17
Eklöf O, Ringertz H (1976) Kidney size in children. Acta Radiol [Diagn] 17(5):617–625
Eklöf O, Ringertz H (1976) Kidney size and growth in unilateral agenesis and in the remaining kidney following nephrectomy for Wilms tumour. Acta Radiol [Diagn] 17(5):601–608
Eklöf O, Lax I, Lundell G, Ringertz H, Wikstad I, Ahström L (1983) Growth of renoprivals following uninephrectomy for Wilms tumour: application and suitability of a method of assessment. Pediatr Radiol 13:272–275
Haugstvedt S, Lundberg J (1980) Kidney size in normal children measured by sonography. Scand J Urol Nephrol 14:251–255
Heideman HD, Rosenbaum HD (1970) A study of renal size after contralateral nephrectomy. Radiology 94:599–601
Hodson CJ (1960) Hypertension of renal origin. In: McLaren JW (ed) Modern trends in diagnostic radiology. Butterworth, London, pp 124–134
Klare B, Geiselhardt B, Wesch H, Schärer K, Immich H, Willich E (1980) Radiological kidney size in childhood. Pediatr Radiol 9: 153–160
Laufer I, Griscom NT (1971) Compensatory renal hypertrophy. AJR 113:464–467
Luttenegger TJ, Gooding CA, Fickenscher LG (1975) Compensatory renal hypertrophy after treatment for Wilms tumour. AJR 125:348–351
Moskowitz PS, Donaldson SS, Canty E (1980) Chemotherapy-induced inhibition of compensatory renal growth in the immature mouse. AJR 134:491–496
Rasmussen SN, Haase L, Kjeldsen H, Hancke S (1978) Determination of renal volume by ultrasound scanning. J Clin Ultrasound 6:160–164
Simon AL (1964) Normal renal size: an absolute criterion. AJR 92:270–272
Simon J, Zamora I, Mendizabal S, Castel V, Lurbe A (1982) Glomerulotubular balance and functional compensation in nephrectomized children. Nephron 31:203–208
Vaeth JM (1964) The remaining kidney in irradiated survivors of Wilms tumour. AJR 92:148–151
Walker HD, Reid CF, Richard GA, Talbert JL, Rogers BM (1982) Compensatory renal growth and function in postnephrectomized patients with Wilms tumour. Urology 21:127–130
Weitzel D, Tröger J, Alzen G, Hub E (1978) Vergleiche zwischen sonographischen, radiologischen und anatomischen Nierenmessungen. In: Kratochwil A, Reinold E (eds) Ultraschalldiagnostik. Thieme, Stuttgart, p 189
Wilton P, Aperia A, Broberger O, Wikstad I (1980) Renal compensatory hypertrophy in children with unilateral renal disease. Acta Paediatr Scand 69:83–88
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dinkel, E., Britscho, J., Dittrich, M. et al. Renal growth in patients nephrectomized for Wilms tumour as compared to renal agenesis. Eur J Pediatr 147, 54–58 (1988). https://doi.org/10.1007/BF00442612
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00442612