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Histoplasmosis in purebred mice: Influence of genetic susceptibility and immune depression on treatment

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Abstract

These experiments demonstrate that susceptibility to Histoplasma infection of the mouse is dramatically influenced by genetic and immunologic factors, and that these factors appear to exert little influence on response to therapy. They further demonstrate that such influence may vary in different visceral organs. The explanation for these observations remains to be elucidated.

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Authors and Affiliations

  1. Research Laboratory in Mycology, Veterans Administration Hospital & Division of Mycological Diseases, Department of Community Medicine, School of Medicine, University of Kentucky, Lexington, Kentucky, USA

    R. Michael Patton M.S., Allan R. Riggs M.S., Suzanne B. Compton B.S., M.T. (ASCP) & Ernest W. Chick M.D.

Authors
  1. R. Michael Patton M.S.
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  2. Allan R. Riggs M.S.
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  3. Suzanne B. Compton B.S., M.T. (ASCP)
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  4. Ernest W. Chick M.D.
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Supported in part by NIH-GRSG Grant RRO5374-13

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Patton, R.M., Riggs, A.R., Compton, S.B. et al. Histoplasmosis in purebred mice: Influence of genetic susceptibility and immune depression on treatment. Mycopathologia 60, 39–43 (1976). https://doi.org/10.1007/BF00442546

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  • DOI: https://doi.org/10.1007/BF00442546

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