Abstract
The fetal epididymis shows a weak periodic acid Schiff (PAS)-positive secretion by the 25th week of gestation which gradually increases during the following weeks and reaches its peak in the later weeks of pregnancy. It decreases again after the 3rd month of life. The organ continues to secrete throughout childhood, although in a much reduced degree. It can be assumed that androgens, produced by the fetus in response to stimulation by maternal and placental hormones, are responsible for the secretion of the organ during fetal life.
The normal development and function of the epididymis in the fetus and infant can be impaired in the presence of various congenital malformations.
Hormonal therapy to the mother during pregnancy may also affect the organ. However, it is possible that in the absence of any serious structural damage to the organ, the purely functional changes may only be of a temporary nature and not detrimental to fertility in later life.
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References
Benirschke, K.: Adrenals in anencephaly and hydrocephaly. Obstet. Gynecol. 8, 412–425 (1956)
Bibbo, M., Gill, W. B., Azizi, F., Blough, R., Fang, V. S., Rosenfeld, R. L., Schumacher, G. F. B., Sleeper, K., Sonek, M. G., Wied, G. L.: Follow-up study of male and female offspring of DES-exposed mother. Obstet. Gynecol. 49, 1–8 (1977)
Ch'in, K. Y.: The endocrine glands of anencephalic foetuses: A quantitative study of 15 cases. Chinese Med. J. Suppl. 2, 63–90 (1938)
Gill, W. B., Schumacher, G. F., Bibbo, M.: Structural and functional abnormalities in the sex organs of male offspring of mothers treated with Diethylstilboestrol (DES). J. Reprod. Med. 16, 147–153 (1976)
Graham, W. H.: Congenital abnormalities of the Kidney. In: Textbook of Genito-Urinary Surgery, 2nd ed. (Winsbury-White, ed.). Edinburg, London: E. and S. Livingstone 1961
Gruber, W.: Mémoire de l'Académie de St. Petersbourg. VIIe Serie, Tome II, No. 2 (1868)
Holstein, A. F.: Morphologische Studien am Nebenhoden des Menschen. In: Zwanglose Abhandlungen aus dem Gebiet der normalen und pathologischen Anatomie, Heft 20. Stuttgart: G. Thieme 1969
Landing, B. H., Wells, T. R., Chun-I Wang: Abnormality of the epididymis and vas deferens in cystic fibrosis. Arch. Path. 88, 569–580 (1969)
Morris, H.: Surgical diseases of the kidney and ureter, Vol. I, p. 22. London: Cassell and Co. Ltd. 1963
Olson, J. R., Weaver, D. K.: Congenital mesonephric defects in male infants with mucoviscidosis. J. Clin. Path. 22, 725–730 (1969)
Pearse, A. G. E.: Personal communication (1964)
Pfeiffer, E.: Die Entwicklung der keimleitenden Wege des Mannes. Z. Mikr. Anat. Forsch. 15, 472 (1928)
Strube, G.: Über kongenitale Lage und Bildungsanomalien der Nieren. Virchows Arch. 137, 227–264 (1894)
Tuchmann-Duplessis, H.: Etude des glandes endocrines des anencéphales. Biol. Neonat. 1, 8–32 (1959)
Tuchmann-Duplessis, H., David, G., Haegel, P.: In: Illustrated Embtyology, Vol. 2: Organogenesis, p. 82. New York: Springer; London: Chapman and Hall; Paris: Masson 1972
Willis, R. A.: The borderland of embryology and pathology, 2nd ed., p. 195. London: Butterworth and Co. Ltd. 1962
Zondek, M.: Die Topographie der Niere und ihre Bedeutung für die Nierenchirurgie, S. 91. Berlin: A. Hirschwald 1903
Zondek, M.: Die chirurgischen Erkrankungen der Nieren und Harnleiter, S. 50–67. Berlin: Springer 1924
Zondek, L. H., Zondek, T.: Observations on the secretory activity of the maturing epididymis in cases of Cryptorchism. Ann. paediat. (Basel) 202, 483–494 (1964a)
Zondek, L. H., Zondek, T.: Observations on the secretory activity of the foetal and neonatal epididymis in cases of congenital malformations of the urinary tract. Ann. paediat. (Basel) 203, 46–58 (1964b)
Zondek, L. H., Zondek, T.: The secretory activity of the human epididymis in Anencephaly. Ann. paediat. (Basel) 294, 301–311 (1965a)
Zondek, L. H., Zondek, T.: The secretory activity of the maturing epididymis compared with maturational changes in other reproductive organs of the Foetus, Infant and Child. Acta Paediat. (Stockh.) 54, 295–304 (1965b)
Zondek, L. H., Zondek, T.: Observations on the Testis in Anencephaly with special reference to the Leydig cells. Biol. Neonat. 8, 329–347 (1965c)
Zondek, L. H., Zondek, T.: Observations on the maturational appearance of the reproductive organs of male infants after treatment with ACTH and Corticosteroids. Helv. Paediat. Acta 29 (2), 173–179 (1974)
Zondek, T.: Notes on the topography of congenital kidney malformations. Brit. J. Urol. 16, 41–50 (1944)
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This paper is dedicated to the memory of our father Professor Dr. Max Zondek, who was a surgeon and urologist in Berlin
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Zondek, L.H., Zondek, T. Normal and abnormal development of the epididymis of the fetus and infant. Eur J Pediatr 134, 39–44 (1980). https://doi.org/10.1007/BF00442401
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DOI: https://doi.org/10.1007/BF00442401