Abstract
The selective D2 dopamine receptor agonist LY 171555 increased defensive behavior dose dependently, decreased social investigation and activity, and increased immobility in mice of the C57BL/6 (C57) strain interacting with non-aggressive mice of the seme strain. In the same test situation, DBA/2 (DBA) mice did not present any increase in defensive behavior following injection of the same doses of LY 171555, while exhibiting a marked decrease in activity and increased immobility. Mice of the BALB/c strain were less responsive than C57 mice as far as defensive behavior was concerned, and showed decreased activity and social investigation and increased immobility. These results point to a major genetic role in the modulation of social behavior by D2 receptors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cabib S, Puglisi-Allegra S (1985) Different effects of apomorphine on climbing behavior and locomotor activity in three strains of mice. Pharmacol Biochem Behav 23:555–557
Cabib S, Puglisi-Allegra S (1988) A classical genetic analysis of two apomo phine-induced behaviors in the mouse. Pharmacol Biochem Behav 30:143–147
Louilot A, Le Moal M, Simon H (1986) Different reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations: an in vivo voltametric study in free moving rats. Brain Res 397:395–400
Miczek KA, Gold LH (1983) d-Amphetamine in squirrel monkeys of different social status: effects on social and agonistic behavior, locomotion and stereotypies. Psychopharmacology 81:183–190
Miczek KA, O'Donnell JM (1978) Intruder-evoked aggression in isolated and nonisolated mice: effects of psychomotor stimulants and l-dopa. Psychopharmacology 57:47–55
Puglisi-Allegra S, Cabib S (1988a) Pharmacological evidence for a role of D2 dopamine receptors in the defensive behavior of the mouse. Behav Neural Biol 50:98–111
Puglisi-Allegra S, Cabib S (1988b) The D2 dopamine receptor agonist LY 171555 induces catalepsy in the mouse. Pharmacol Biochem Behav 30(3):765–768
Upchurch M, Schallert T (1982) Neuroleptic-sensitive posture and movement related to subordinate social status in mongolian gerbils (Meriones unguiculatus). Behav Neural Biol 35:308–314
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cabib, S., Puglisi-Allegra, S. Genotype-dependent modulation of LY 171555-induced defensive behavior in the mouse. Psychopharmacology 97, 166–168 (1989). https://doi.org/10.1007/BF00442243
Issue Date:
DOI: https://doi.org/10.1007/BF00442243