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Tumoral calcinosis revisited — common and uncommon features

Report of ten cases and review

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Abstract

Familial cutaneous and subcutaneous tumoral calcifications are a recognized entity of unknown pathogenesis. The course of calcinosis and various treatments are discussed and the literature concerning the aetiology is reviewed. Our ten cases provided some experience in dealing with tumoral calcinosis and demonstrated, in addition, some clinical phenomena unrecognized previously, such as involvement of the mucous membranes and an ertthematous rash preceeding the development of calcified nodules.

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Abbreviations

TC:

tumoral calcinosis

Pi:

phosphorus, inorganic

References

  1. Annamunthodo H (1960) Calcinosis. Am J Surg 99:951–955

    Google Scholar 

  2. Baldurson H, Evans EB, Dodge WF, Jackson WT (1969) Tumoral calcinosis with hyperphosphatemia. J Bone Joint Surg 51A:913–925

    Google Scholar 

  3. Barton DL, Reeves RJ (1961) Tumoral calcinosis. Am J Roentgenol 86:351–358

    Google Scholar 

  4. Bostrum B (1981) Tumoral calcinosis in an infant. Am J Dis Child 135:246–247

    Google Scholar 

  5. Collard M (1966) Une forme familiale de lipocalcinogranulomatose avec calcinose arterielle. J Radiol Electrol 47:31–40

    Google Scholar 

  6. Cram RL, Barmada R, Geho WB, Ray RD (1971) Diphosphonate treatment of calcinosis universalis. N Engl J Med 285:1012–1013

    Google Scholar 

  7. Duret MH (1899) Tumeurs multiple et singulieres des bourses sereuses. Bull Soc Anat Paris 74:725–731 Cited by Wilber JF, Slatopolsky E (1980) Ann Intern Med 68:1044–1049

    Google Scholar 

  8. Inclan A (1943) Tumoral calcinosis. J Am Med Assoc 121:490–495

    Google Scholar 

  9. Katzenellenbogen I, Sandbank M (1963) Generalized calcinosis in childhood. Acta Derm Venereol 43:76–85

    Google Scholar 

  10. Lafferty FW, Reynolds ES, Pearson OH (1965) Tumoral calcinosis. A metabolic disease of obscure etiology. Am J Med 38: 105–118

    Google Scholar 

  11. Lufkin EG, Wilson DM, Smith LH, Bill NJ, Deluca HF, Dousa TP, Knox FG (1979) Phosphorus excretion in tumoral calcinosis: response to parathyroid hormone and acetazolamide. J Clin Endocrinol Metab 50:648–653

    Google Scholar 

  12. McClatchie S, Brenner AD (1969) Tumoral calcinosis — an unrecognized disease. Br Med J 1:153–155

    Google Scholar 

  13. McKee PH, Liomba NG, Hutt MSR, (1982) Tumoral calcinosis: a pathological study of fifty-six cases. Br J Dermatol 107:669–674

    Google Scholar 

  14. Melhem RE, Najjar SS, Khachadurian AK (1970) Cortical hyperostosis with hyperphosphatemia: a new syndrome? J Pediatr 77: 986–990

    Google Scholar 

  15. Metzger AL, Singer FR, Bluestone R, Pearson CM (1974) Failure of disodium etidronate in calcinosis due to dermatomyositis and scleroderma. N Engl J Med 291:1294–1296

    Google Scholar 

  16. Mikati MA, Melhem RE, Najjar SS (1981) The syndrome of hyperostosis and hyperphosphatemia. J Pediatr 99:900–904

    Google Scholar 

  17. Mitnick PD, Goldfarb S, Slatopolsky E, Lemann J, Gray RW, Agus ZS (1980) Calcium and phosphate metabolism in tumoral calcinosis. Ann Intern Med 92:482–487

    Google Scholar 

  18. Mozafarian G, Lafferty FW, Pearson OH (1972) Treatment of tumoral calcinosis with phosphorus deprivation. Ann Intern Med 77:741–745

    Google Scholar 

  19. Muhlbauer RC, Fleisch H (1981) Effect of various polyphosphonates on ectopic calcification and bone resorption in rats. Miner Electrolyte Metab 5:296–303

    Google Scholar 

  20. Najjar SS, Farah FS, Kurban AK, Melhem RE, Katchadurian AK (1968) Tumoral calcinsis and pseudoxanthoma elasticum. J Pediatr 72:243–247

    Google Scholar 

  21. Pursley TV, Prince MJ, Chausmer AB, Raimer SS (1979) Cutaneous manifestations of tumoral calcinosis. Arch Dermatol 115:1100–1102

    Google Scholar 

  22. Smith GG, Schmanan A (1967) Tumoral calcinosis. J Bone Joint Surg 49A:698–703

    Google Scholar 

  23. Stark H, Eisenstein B, Tieder M, Rachmel A, Alpert G (1986) Direct measurement of TP/GFR. A simple and reliable parameter of renal phosphate handling. Nephron 44:125–128

    Google Scholar 

  24. Steinherz R, Chesney RW, Eisenstein B, Metzker A, DeLuca HF, Phelps M (1985) Elevated serum calcitriol concentrations do not fall in response to hyperphosphatemia in familial tumoral calcinosis. Am J Dis Child 139:816–819

    Google Scholar 

  25. Teissir LJ (1877) Du diabete phosphatique. These de Paris 1877. Cited by: Davis H, Moe PJ (1959) Pediatrics 24:780–785

  26. Zerwekh JE, Sanders LA, Townsend J, Pak CYC (1980) Tumoral calcinosis: evidence for concurrent defects in renal tubular phosphorus transport and in 1.25 dihydroxycholecalciferol synthesis. Calcif Tissue Int 32:1–6

    Google Scholar 

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Metzker, A., Eisenstein, B., Oren, J. et al. Tumoral calcinosis revisited — common and uncommon features. Eur J Pediatr 147, 128–132 (1988). https://doi.org/10.1007/BF00442209

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  • DOI: https://doi.org/10.1007/BF00442209

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