Skip to main content
SpringerLink
Log in

Statistical analysis of statural growth following kidney transplantation

  • Original Investigations
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Factors affecting the growth rates of 59 children and adolescents for the first 2 years following kidney transplantation were evaluated. The factors assessed were age at transplantation, renal function, prednisone dosage, donor source, and prior history of transplantation. The observed growth velocity was expressed as the percentage of the growth velocity predicted by bone age. Normal growth (≥80%) was exhibited by 37% of the patients and 22% had accelerated growth (≥100%). The chronological age at transplantation did not correlate significantly with growth when bone age was used as the reference for expected velocity. Males grew better than did females. There was a unique sex/race interaction with black males growing most rapidly. Better renal function, the ability to lower prednisone dosage, alternate day prednisone, and a decreasing diastolic blood pressure were positively correlated with better growth rates after transplantation. Donor source and prior history of transplantation did not significantly influence growth rate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baum M, Powell D, Calvin S, McDaid T, McHenry K, Mar H, Potter D (1982) Continuous ambulatory peritoneal dialysis in children, comparison with hemodialysis. N Engl J Med 307:1537–1542

    Google Scholar 

  2. Broyer M, Gagnadoux MF, Beuton D, Pascal B, Louville J (1981) Transplantation in children: technical aspects, drug therapy and problems related to primary renal disease. Proc Eur Dial Transplant Assoc 18:313–342

    Google Scholar 

  3. Chanther C, Carter JE, Bewick M, Counahan R, Cameron JS, Ogg Cs, Williams DG, Winder E (1980) Ten years experience with regular hemodialysis and renal transplantation. Arch Dis Child 55:435–445

    Google Scholar 

  4. DeShazo CV, Simmons RL, Bernstein DM, DeShazo MM, Willmert J, Kjellstrand CM, Najarian JS (1974) Results of renal transplantation in 100 children. Surgery 76:461–468

    Google Scholar 

  5. Feldhoff C, Goldman A, Najarian J, Mauer S (1984) A comparison of alternate day and daily steroid therapy in children following renal transplantation. Int J Pediatr Nephrol 5:11–14

    Google Scholar 

  6. Fennell RS, Garin EH, Pfaff W, Brient B, Iravani A, Walker RD, Richard GS (1979) Renal transplantation in children and adolescents. Clin Pediatr 18:518–532

    Google Scholar 

  7. Fennell RS, Zalenski R, Geary DF, Iravani A, Garin EH, Pfaff WW, Howard RJ, Brient BW, Walker D, Richard GA (1981) Hypertension in a pediatric and adolescent population following kidney transplantation. Int J Pediatr Nephrol 2:89–95

    Google Scholar 

  8. Fennell RS, Orak JK, Hudson T, Garin EH, Iravani A, Van Deusen WJ, Howard R, Pfaff WW, Walker RD, Richard GA (1984) Growth in children with various therapies for end-stage renal disease. Am J Dis Child 138:28–31

    Google Scholar 

  9. Fine RN, Grushkin CM (1973) Hemodialysis and renal transplantation in children. Clin Nephrol 1:243–256

    Google Scholar 

  10. Fine RN, Edelbrook HH, Riddell H, Malekzadeh MH, Pennisi AJ, Ettenger RB, Micheal AF (1977) Renal transplantation in children. Urology [Suppl] 9:61–71

    Google Scholar 

  11. Fine RN, Malekzadeh MH, Pennisi AJ, Ettenger RB, Vittenbogaart C, Korsch BM (1977) Cadaver renal transplantation in children. Transplant Proc 9:133–136

    Google Scholar 

  12. Fine RN, Malekzadeh MH, Pennisi AJ, Ettenger RB, Vittenbogaart CH, Negrete VF, Korsch BM (1978) Long-term results of renal transplantation in children. Pediatrics 61:641–650

    Google Scholar 

  13. Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hands and wrists, 2nd edn. Stanford University Press, California

    Google Scholar 

  14. Hoda Q, Hasinoff DJ, Arbus GS (1975) Growth following renal transplantation in children and adolescent. Clin Nephrol 3:6–9

    Google Scholar 

  15. Hodson EM, Najarian JS, Kjellstrand CM, Simmons RL, Mauer SM (1978) Renal transplantation in children, ages 1 to 5 years. Pediatrics 61:458–464

    Google Scholar 

  16. Ingelfinger JR, Grupe WE, Harmon WE, Fernbach SK, Levey RH (1981) Growth acceleration following renal transplantation in children less than 7 years of age. Pediatrics 68:255–259

    Google Scholar 

  17. Lewy JE, New MI (1975) Growth in children with renal failure. Am J Med 58:65–68

    Google Scholar 

  18. Martin LW, McEnery PT, Rosenkrantz JG, Cox JA, West CD, LeCoultre C (1979) Renal homotransplantation in children. J Pediatr Surg 14:571–576

    Google Scholar 

  19. McEnery PT, Gonzalez LL, Martin LW, West CD (1973) Growth and development of children with renal transplants. Use of alternate-day steroid therapy. J Pediatr 83:806–814

    Google Scholar 

  20. Najarian JS, Simmons RL, Tallent MB, Kjellstrand CM, Buselmeier TJ, Vernier RL, Michael AF (1971) Renal transplantation in infants and children. Ann Surg 174:583–601

    Google Scholar 

  21. Pennisi AJ, Costin G, Phillips LS, Vittenbogaart CH, Korsch BM (1977) Linear growth in long-term renal allograft recipients. Clin Nephrol 8:415–421

    Google Scholar 

  22. Pennisi AJ, Costin G, Phillips LS, Malekzaheh MM, Vittenbogaart C, Ettenger RS, Fine RN (1979) Somatomedin and growth hormone studies in pediatric renal allograft recipients who receive daily prednisone. Am J Dis Child 133:950–954

    Google Scholar 

  23. Petrusick TW, Cunningham RJ, Brouhard BH, Berger M, Travis LB (1978) Enhanced growth following renal transplantation utilizing alternate-day steroid therapy. Proc Clin Dial Transplant Forum 8:18–20, 73–77

    Google Scholar 

  24. Potter DE, Greifer I (1978) Statural growth of children with renal disease. Kidney Int 14:334–339

    Google Scholar 

  25. Potter DE, Belzer FO, Rames L, Holliday MA, Kountz SL, Najarian JS (1970) The treatment of chronic uremia in chhildhood. I. Transplantation. Pediatrics 45:432–443

    Google Scholar 

  26. Reimold EW (1973) Intermittent prednisone therapy in children and adolescents after renal transplantation. Pediatrics 52:235–240

    Google Scholar 

  27. Report of the task force on blood pressure control in children (1977) Pediatrics [Suppl] 59:797–820

    Google Scholar 

  28. Saenger P, Wiedemann E, Schwartz E, Koerh-Schutz S, Lewy JE, Riggio RR, Rubin AL, Stenzel KH, New MI (1974) Somatomedin and growth after renal transplantation. Pediatr Res 8:163–169

    Google Scholar 

  29. Searle SR (1971) Linear models. Wiley, New York

    Google Scholar 

  30. Stefanidis CJ, Hewitt LK, Balfe JW (1983) Growth in children receiving continuous ambulatory peritoneal dialysis. J Pediatr 102:681–685

    Google Scholar 

  31. Tanner JM, Whitehouse RH, Takaishi M (1966) Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children. II. 1965. Arch Dis Child 41:623–635

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Florida, College of Medicine, Box J-296, 32610, Gainesville, FL, USA

    R. S. Fennell III, W. Van Deusen, E. H. Garin, A. Iravani & G. A. Richard

  2. Department of Radiology, University of Florida, Gainesville, Florida, USA

    T. M. Hudson

  3. Department of Surgery, University of Florida, Gainesville, Florida, USA

    W. W. Pfaff & R. J. Howard

  4. Department of Biostatistics, University of Florida, Gainesville, Florida, USA

    J. T. Love & R. L. Carter

  5. Deparment of Urology, University of Florida, Gainesville, Florida, USA

    R. D. Walker III

Authors
  1. R. S. Fennell III
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. T. Love
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. L. Carter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. M. Hudson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. W. Pfaff
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. J. Howard
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. Van Deusen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. H. Garin
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. Iravani
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. R. D. Walker III
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. G. A. Richard
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by The Comprehensive Children's Kidney Failure Center Grant from the Children's Medical Services, a program of the State of Florida Department of Health and Rehabilitative Services

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fennell, R.S., Love, J.T., Carter, R.L. et al. Statistical analysis of statural growth following kidney transplantation. Eur J Pediatr 145, 86–89 (1986). https://doi.org/10.1007/BF00441863

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00441863

Key words

Search

Navigation