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Difficult hGH treatment in a patient with type III glycogen storage disease

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Abstract

The case of a boy affected by type III glycogen storage disease and total GH deficiency is reported. Substitutive treatment with hGH caused an extreme elevation of blood lipids. His lipid profile returned near to basal values 1 month after treatment was discontinued. The association of growth hormone and amylo-1-6-glucosidase deficiencies is unusual and difficult to treat; however growth hormone deficiency should be considered in patients with hepatic glycogenoses and severe growth retardation.

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Abbreviations

GH:

growth hormone

References

  1. Alagille D, Odievre M (1978) Maladies du foie et des voies biliaires chez l'enfant. Flammarion Medicine Sciences Paris 168–175

  2. Bierich JR, Rager K, Schonberg D (1973) Endocrinological findings in patients with glycogenosis. Acta Endocrinol [Suppl] (Copenh) 173:128

    Google Scholar 

  3. Dunger DB, Leonard JV, Preece MA (1984) Patterns of growth in the hepatic glycogenoses. Arch Dis Child 59:657–660

    Google Scholar 

  4. Friedman M, Byers SO, Rosenman RA, Li CH, Neuman R (1974) Effect of subacute administration of human growth hormone on various serum lipid and hormone levels of hypercholesterolemic and normocholesterolemic subjects. Metabolism 23:905

    Google Scholar 

  5. La Cauza C, Maranelli L, Nicotina PA, Seminara S, Salti R, Godi R (1977) Somatomedins and carbohydrate metabolism. In: Chiumello G, Laron Z (eds) Recent progress in paediatric endocrinology, vol 12. Academic Press, London

    Google Scholar 

  6. Lockwood DH, Merimee TJ, Edgard PJ, Green HL, Fujimoto MY, Seegmiller JE, Howell RR (1969) Insulin secretion in type I glycogen storage disease. Diabetes 18:755–759

    Google Scholar 

  7. Muggeo M, Tiengo A, Fedele D, Crepaldi G (1975) Growth hormone secretion in primary endogenous hypertriglyceridemie. Horm Metab Res 5:224

    Google Scholar 

  8. Okada S, Seino Y, Kodama H, Yutaka T, Inui K, Ishida M, Yabuuchi H, Seino Y (1979) Insulin and glucagon secretion in hepatic glycogenoses. Acta Paediatr Scand 68:735–738

    Google Scholar 

  9. Rona RJ, Tanner JM (1977) Aetiology of idiopathic growth hormone deficiency in England and Wales. Arch Dis Child 52:197–280

    Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, I and II Chair, University of Pavia, Pavia, Italy

    D. Larizza, G. Maggiore, D. Marzani, M. Maghnie & R. Ciceri

Authors
  1. D. Larizza
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  2. G. Maggiore
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  3. D. Marzani
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  4. M. Maghnie
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  5. R. Ciceri
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Larizza, D., Maggiore, G., Marzani, D. et al. Difficult hGH treatment in a patient with type III glycogen storage disease. Eur J Pediatr 145, 84–85 (1986). https://doi.org/10.1007/BF00441862

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  • DOI: https://doi.org/10.1007/BF00441862

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