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Chemistry and pharmacology of compounds related to 4-(4-hydroxy-4-phenyl-piperidino)-butyrophenone

Part IV influence of haloperidol (R 1625) and of chlorpromazine on the behaviour of rats in an unfamiliar “open field” situation

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Summary

Haloperidol (R 1625) is 50 to 100 times more active than chlorpromazine as an inhibitor of exploratory motor behaviour in rats. Emotional defaecation in rats is inhibited by both drugs at similar dose levels.

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Authors and Affiliations

  1. Research Laboratorium Dr. C. Janssen, Beerse, Belgium

    Paul A. J. Janssen, Anton H. M. Jageneau & Karel H. L. Schellekens

Authors
  1. Paul A. J. Janssen
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  2. Anton H. M. Jageneau
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  3. Karel H. L. Schellekens
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Thanks are due to Mr. Remi Frederickx for his technical assistance.

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Janssen, P.A.J., Jageneau, A.H.M. & Schellekens, K.H.L. Chemistry and pharmacology of compounds related to 4-(4-hydroxy-4-phenyl-piperidino)-butyrophenone. Psychopharmacologia 1, 389–392 (1960). https://doi.org/10.1007/BF00441186

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  • DOI: https://doi.org/10.1007/BF00441186

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