Abstract
Data are presented on 121 dwarfed patients belonging to 98 Israeli families with 4 types of dwarfism related to deficiency or in activity of human growth hormone (hGH): isolated growth hormone deficiency (IGHD), partial hGH deficiency (pIGHD), multiple pituitary hormone deficiencies (MPHD) and Larontype dwarfism (LTD). These series are believed to comprise most of the dwarfs of these types in Israel; however, their distribution among the various ethnic communities varies greatly: LTD (15 families) is confined to a few communities of Oriental Jews; only 3 of 30 families with IGHD, but 7 of 10 families with pIGHD, are Ashkenazi, whereas the ethnic distribution of 42 families with MPHD corresponds roughly to that of the general population. These data seem to reflect the role of genetic factors in the etiology of the various types of dwarfism: the stronger the genetic component, the greater is its deviation from random occurrence among the various communities.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Adler-Bier M, Pertzelan A, Laron Z, Leiberman E, Moses S (1979) Multiple pituitary hormone deficiencies in eight siblings of one Jewish Moroccan family. Acta Paediat Scand 68:401–404
Bierich JR (1962) The function of the adenohypophysis in pituitary dwarfism. Acta Endocrinol (Kbh) [Suppl] 67:76
Crow JF (1965) Problems of ascertainment in the analysis of family data. In: Neel JV, Shaw MW, Schull WJ (eds) Genetics and the epidemiology of chronic diseases. US Public Health Service Publication
Dickerman Z, Prager-Lewin R, Laron Z (1976) The effect of repeated injections of synthetic luteinizing hormone-releasing hormone on the response of plasma luteinizing hormone and follicle stimulating hormone in young hypogonadotrophic hypogonadal patients. Fertil Steril 27:162–166
Foley TP Jr, Jacobs LS, Hoffman W, Daughaday WH, Blizzard RM (1972) Human prolactin and thyrotropin concentrations in the serum of normal and hypopituitary children before and after the administration of synthetic thyrotropin releasing hormone. J Clin Invest 51:2143–2150
Gil-Ad I, Topper E, Laron Z (1979) Oral clonidine as a growth hormone stimulation test. Lancet II:278–280
Goodman RM (1979) Genetic disorders among the Jewish People. Johns Hopkins University Press, Baltimore London
Gourmelen M, Pham-Trung MT, Girard F (1979) Transient partial hGH deficiency in prepubertal children with delay of growth. Pediatr Res 13:221–224
Gurewitz R, Cader Y, Kauli R, Keret R, Laron Z (1980) Comparison between growth hormone secretion during sleep and provocative tests in children and adolescents. Harefuah 108:53–56
Laron Z, Pertzelan A, Karp M (1968) Pituitary dwarfism with high serum levels of growth hormone. Israel J Med Sci 4:883–894
Laron Z (1969) The hypothalamus and the pituitary gland (hypophysis). In: Hubble DW (ed) Paediatric endocrinology. Blackwell Scientific Publications, Oxford, pp 35–111
Laron Z, Pertzelan A, Karp M, Kowadlo-Silbergeld A, Daughaday WH (1971) Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone. Measurement of sulfation factor, metabolic and linear growth responses. J Clin Endocrinol Metab 33:332–342
Laron Z, Karp M, Pertzelan A, Kauli R, Keret R, Doron M (1972) The syndrome of familial dwarfism and high plasma immunoreactive human growth hormone (IR-hGH). In: Pecile A, Muller EE (eds) Growth and growth hormone. Excerpta Medica, Amsterdam, pp 458–482
Laron Z, Josefsberg Z, Doron M (1973) Effect of l-Dopa on the secretion of plasma growth hormone in children and adolescents. Clin Endocrinol 2:1–7
Laron Z (1976) Somatic growth of children in warm climates. In: Wasz-Hockert (ed) Nordic Council Arctic Medical Research Report No 14, pp 15–24
Laron Z (1977) Syndrome of familial dwarfism and high plasma immunoreactive growth hormone (IR-hGH)—Laron-type dwarfism. Paediatrician 6:106–117
Laron Z, Kowadlo-Silbergeld A, Eshet R, Pertzelan A (1980) Growth hormone resistance. Ann Clin Res 12:269–277
McKusick VA (1975) Mendelian inheritance in man, 5th edn. Johns Hopkins University Press, Baltimore London
Pertzelan A, Adam A, Laron Z (1968) Genetic aspects of pituitary dwarfism due to absence or biological inactivity of growth hormone. Israel J Med Sci 4:895–900
Rona RJ, Tanner JM (1977) Aetiology of idiopathic growth hormone deficiency in England and Wales. Arch Dis Childh 52:197–208
Statistical Abstract of Israel No 30 (1980) Central Bureau of Statistics, Sivian Press, Jerusalem
Steendijk R (1980) Diagnostic and aetiologic features of idiopathic and symptomatic growth hormone deficiency in the Netherlands. Helv Paediat Acta 35:129–139
Van Der Werff Ten Bosch JJ (1962) Hypofisaire dwerggroei. Ned T Geneeske 106:1282–1294
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Adam, A., Josefsberg, Z., Pertzelan, A. et al. Occurrence of four types of growth hormone-related dwarfism in Israeli communities. Eur J Pediatr 137, 35–39 (1981). https://doi.org/10.1007/BF00441167
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00441167