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A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique

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Summary

Quantitative studies of the influence of anticonvulsant drugs on bone mineral content of 88 epileptics were performed by a microcomputer-aided densitometer system. The results showed that the mineral content decreases significantly with the duration of the therapy. This decrease was found to be approximately 1.2% per year for a Diphenylhydantoin (DPH) monotherapy and 1.8% per year and 2.0% per year for a DPH plus Phenobarbital and DPH plus Carbamazepin combination therapy.

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Authors and Affiliations

  1. Institute of Applied Physics, Kiel, FRG

    K. Wolschendorf & K. Vanselow

  2. Department of Neurology, University of Kiel, Kiel, FRG

    W. -D. Möller & H. Schulz

Authors
  1. K. Wolschendorf
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  2. K. Vanselow
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  3. W. -D. Möller
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  4. H. Schulz
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Wolschendorf, K., Vanselow, K., Möller, W.D. et al. A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique. Neuroradiology 25, 315–318 (1983). https://doi.org/10.1007/BF00439210

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  • DOI: https://doi.org/10.1007/BF00439210

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