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Leukocyte-endothelial adhesion and angiogenesis in tumors

  • Tumor Angiogenesis
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Abstract

Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.

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Authors and Affiliations

  1. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, 02114, Boston, MA, USA

    Rakesh K. Jain, Gerald C. Koenig, Marc Dellian, Dai Fukumura, Lance L. Munn & Robert J. Melder

  2. Harvard Medical School, 02114, Boston, MA, USA

    Rakesh K. Jain, Gerald C. Koenig, Marc Dellian, Dai Fukumura, Lance L. Munn & Robert J. Melder

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  1. Rakesh K. Jain
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  2. Gerald C. Koenig
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  4. Dai Fukumura
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  6. Robert J. Melder
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Jain, R.K., Koenig, G.C., Dellian, M. et al. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metast Rev 15, 195–204 (1996). https://doi.org/10.1007/BF00437472

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