Abstract
Hendersonula toruloidea (HT) is a dematiaceous fungus that is an endemic human pathogen in tropical and subtropical countries. Infection with this fungus is often clinically indistinguishable from Trichophyton rubrum or other dermatophytoses. However, because HT will not grow on standard cycloheximide containing fungal media, and because HT is usually resistant to standard anti-fungal therapies, we believe that HT is a more common cause of ‘recalcitrant dermatophytosis’ in the United States than is currently recognized. HT may be especially prevalent among immigrant patients from endemic countries. We report the first cases of HT to occur in a non-endemic region of the United States. This suggests that HT may become a significant pathogen in the native American host as well. Moreover, we report the first case of a tinea capitis-like infection due to HT.
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Allison VY, Hay RJ, Campbell CK. Hendersonula toruloidea and Scytalidium hyalinum infections in Tobago. Br J Dermatol 1984; 111: 371–2.
Al-Zarari, Attrackchi AA, Tarabeib AM et al. New hosts for Hendersonula toruloidea. Pak J Sci Ind Res 1979; 22: 251.
Burghi AL, de Bracalent BJC. Onicomicosis por dermatiacea. Rev Latamar Microbiol 1986; 28: 63–6.
Campbell CK. Studies on Hendersonula toruloidea isolated from human skin and nail. Sabouraudia 1971; 12: 150–6.
Campbell CK. Hyphal wall swellings in Hendersonula toruloidea. Trans Br Mycol Soc 1976: 66: 158–60.
Campbell CK, Kurwa A, Abdel-Aziz AHM et al. Fungal infection of skin an nail by Hendersonula toruloidea. Br J Dermatol 1973; 89: 45–52.
Carruthers JA, Stein L, Black WA. Persistent skin and nail infection by an exotic fungus, Hendersonula toruloidea. Can Med Assoc J 1982; 127: 608.
Drouhet E, Drouhet B. Laboratory and clinical assessment of ketoconazole in deep-seated mycoses. Am J Med 1983; 74: 30–47.
Eady R, Moore M. Hendersonula toruloidea infection of the skin and nails. Trans St Johns Hosp 1974; 60: 104–8.
English MP. Nail and fungi. Br J Dermatol 1976; 94: 597–701.
Evans EGV, Hose H. In vitro degradation of human hair by Hendersonula toruloidea. Sabouraudia 1975; 13: 323–8.
Gentles JC, Evans EGV. Infection of the feet and nails with Hendersonula toruloidea. Sabouraudia 1970; 8: 72–5.
Gentles JC, Scott E. Superficial mycoses in the West of Scotland. Scot Med J 1982; 26: 328–35.
Greer DL, Guitierrez MM. Tinea pedis caused by Hendersonula toruloidea. J Am Acad Dermatol 1987; 16: 1111–5.
Gugnani HC, Nzelibe FK, Osunkwo IC. Onychomycosis due to Hendersonula toruloidea in Nigeria. J Med Vet Mycol 1986; 24: 239–41.
Hay RJ, Mackie RM, Clayton YM. Ticonazole nail solution-an open study of its efficacy in onychomycosis. Clin Exp Dermatol 1985; 10: 111–5.
Hay RJ, Wells RS, Clayton YM et al. The use of oral ketoconazole on chronic resistant fungal infection of the skin. Br J Dermatol 1980; 103: 22–3.
Hay RJ. Ketoconazole in the treatment of fungal infection. Am J Med 1983; 74: 16–9.
Hay RJ, Moore MK. Clinical features of superficial infection caused by Hendersonula toruloidea and Scytalidium hyalinum. Br J Dermatol 1984; 110: 677–83.
Jones SK, White Je, Jacobs PH et al. Hendersonula toruloidea infection in the nails of caucasians. Clin Exp Dermatol 1985; 10: 444–7.
Kong BHP, Kapica L, Lee R. Keratin invasion by Hendersonula toruloidea. Int J Dermatol 1984; 23: 65–6.
Kurwa A, Campbell C. Hendersonula toruloidea infection. Br J Dermatol 1972; 86: 98–9.
Mariat F, Liautaud R, Liautaud M et al. Hendersonula toruloidea, agent d'une dermatite verruqueuse mycosique observée in algerie. Sabouraudia 1978; 16: 133–40.
Moore MK. Skin and nail infections by non-dermatophyte filamentous fungi. Mycosen Supp 1978; 1: 128–32.
Moore MK. Hendersonula toruloidea and Scytalidium hyalinum infection in London, England. J Med Vet Mycol 1986; 24: 219–30.
Moore MK, Hay RJ. Circulating antibodies and antigens crossreacting in Hendersonula toruloidea and Scytalidium hyalinum infection. Br J Dermatol 1986; 115: 435–45.
Moore MK. May 8, 1987. Personal communication.
Nattrass RM. A new species of Hendersonula (H. toruloidea) on deciduous trees in Egypt. Trans Brit Mycol Soc 1933; 18: 189–97.
Peiris S, Moore MK, Marten RH. Scytalidium hyalinum infection on skin and nails. Br J Dermatol 1979; 100: 579–84.
Rippon JW. Medical mycology (3rd ed), 1988. Philadelphia, Saunders, p269.
Rosman N. Imported superficial fungal infections in Denmark. Curr Therap Res 1977; 22: 100–3.
Rush-Munro FM. The mycoses of man in New Zealand. In: Kuttin ES, Baum GL, eds. Human and animal mycology; Proceedings of the VII Congress of ISHAM, Jerusalem, Israel, March 11–6, 1979. Amsterdam. Exerpta Medica, 1980.
Singh SM, Barde AK. Hendersonula toruloidea infection of human skin and nails. Ind J dermatol Venereol Lepr 1980; 46: 350–5.
Turvey JWJ, English MP, Phillips MN. Tinea pedis caused by Hendersonula toruloidea. Chiropodist 1979; 34: 64–5.
Wildfever VA. Die wirking von pimaricin gegen Hendersonula toruloidea in experimentellen untersuchungen. Arzneim-Forsch (Drug Res) 1972; 22: 101–4.
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Frankel, D.H., Rippon, J.W. Hendersonula toruloidea infection in man. Mycopathologia 105, 175–186 (1989). https://doi.org/10.1007/BF00437252
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DOI: https://doi.org/10.1007/BF00437252