Skip to main content
Log in

Concentrations of fumonisin B1 in feeds associated with animal health problems

  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

Ninety-eight samples of feeds associated with 44 cases of equine leukoencephalomalacia (ELEM) and 83 samples of feed associated with 42 cases of a porcine pulmonary edema syndrome (PPE) were analyzed for fumonisin B1 (FB1). For comparison purposes, 51 feed samples not associated with PPE or ELEM were also analyzed. Feed associated with ELEM contained FB1 ranging from less than 1 μg/g to 126 μg/g with 75% of the cases having at least 1 sample above 10 μg/g. Feeds associated with PPE ranged from less than 1 μg/g to 330 μg/g with 71% of the cases having at least 1 sample greater than 10 μg/g. Quantitation was by high performance liquid chromatography (HPLC)/fluorescence using the fluorescamine derivative with confirmation by thin layer chromatography (TLC) and/or gas chromatography/mass spectroscopy (GC/MS).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bezuidenhout SC, Wentzel CA, Gelderbloom WPA, et al. Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. J Chem Soc Chem Comm 1988; 743–5.

  2. Gelderblom WCA, Jaskiewic K, Marasas WFO, et al. Fumonisins — Novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Envir Microbiol 1988; 54: 1806–11.

    Google Scholar 

  3. Brownie CF, Cullen J. Characterization of experimentally induced equine leukoencephalomalacia (ELEM) in ponies (Equiscaballus): Preliminary Report. J Vet Human Toxicol 1987; 29: 34–38.

    Google Scholar 

  4. McCue PM. Equine leukoencephalomalacia. The Compendium 1989; 11: 646–51.

    Google Scholar 

  5. Wilson BJ, Maronpot RR. Causative fungus agent of leukoencephalomalacia in equine animals. Vet Record 1971; 88: 484–6.

    Google Scholar 

  6. Marasas WFO, Kellerman TS, Gelderblom WCA, et al. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J Vet Res 1988; 55: 197–203.

    Google Scholar 

  7. Kriek NPJ, Kellerman TS, Marasas WFO. A comparative study of the toxicity of Fusarium verticillioides (-F. moniliforme) to horses, primates, pigs, sheep, and rats. Onderstepoort J Vet Res 1981; 48: 129–31.

    Google Scholar 

  8. Norred WP, Plattner RD, Voss KA, et al. Natural occurrence of fumonisins in corn associated with equine leukoencephalomalacia (ELEM). Toxicologist 1989; 9: 258.

    Google Scholar 

  9. Sydenham EW, Gelderblom WCA, Thiel PG, Marasas WFO. Evidence for the natural occurrence of fumonisin B1, a mycotoxin produced by Fusarium moniliforme, in corn. J Agric Food Chem 1990; 38: 286–90.

    Google Scholar 

  10. Voss KA, Norred WP, Plattner RD, Bacon CW. Hepatotoxicity and renal toxicity in rats of corn samples associated with field cases of equine leukoencephalomalacia. Food Chem Toxicol 1989; 28: 89–96.

    Google Scholar 

  11. Wilson TM, Ross PF, Rice LG, Osweiler GD, Nelson HA, Owens DL, Plattner RD, Reggiardo C, Noon TH, Pickrell JW. Fumonisin B1, levels associated with an epizootic of equine leukoencephalomalacia. J Vet Diag Invest 1990; 2 (3): 213–6.

    Google Scholar 

  12. Harrison LR, Colvin BM, Greene JT, Newman LE, Cole JR. Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J Vet Diag Invest 1990; 2 (3): 210–2.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ross, P.F., Rice, L.G., Plattner, R.D. et al. Concentrations of fumonisin B1 in feeds associated with animal health problems. Mycopathologia 114, 129–135 (1991). https://doi.org/10.1007/BF00437200

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00437200

Key words

Navigation