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Susceptibility of clinical isolates of yeasts to anti-fungal agents

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Abstract

The antimicrobial activity of amphotericin B, 5-fluorocytosine, nystatin, clotrimazole and miconazole were compared in vitro against 244 strains of yeasts that had been isolated from clinical specimens. The yeasts used in this study included 20 species of Candida, Cryptococcus, Saccharomyces Geotrichum, Rhodotorula, Torulopsis and Trichosporon. The majority of the strains (78%) had an MIC of ≤0.5 μg/ml for amphotericin B, 81% an MIC of ≤1 μg/ml for 5-fluorocytosine, 99% ≤8 μg/ml for nystatin, 91%, ≤8.0 μg/ml for clotrimazole and 98% had an MIC of ≤4.0 for miconazole. Of the anti-fungal agents tested, 5-fluorocytosine and nystatin were found to have the greatest antifungal activity.

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Authors and Affiliations

  1. University of Oklahoma Health Science Center, Oklahoma City, Oklahoma

    S. M. H. Hussain Qadri & D. J. Flournoy

  2. Veterans Administration Medical Center, Oklahoma City, Oklahoma, USA

    D. J. Flournoy

  3. Hospital Regional Zone Norte Petroleos Mexicanos, Cd. Madero, Tam., Mexico

    S. G. M. Qadri & E. G. Ramirez

Authors
  1. S. M. H. Hussain Qadri
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  2. D. J. Flournoy
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  3. S. G. M. Qadri
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  4. E. G. Ramirez
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Hussain Qadri, S.M.H., Flournoy, D.J., Qadri, S.G.M. et al. Susceptibility of clinical isolates of yeasts to anti-fungal agents. Mycopathologia 95, 183–187 (1986). https://doi.org/10.1007/BF00437125

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  • DOI: https://doi.org/10.1007/BF00437125

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