Skip to main content
Log in

Aspergillus myositis in a patient with a myelodysplastic syndrome

  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

We present the case of an elderly man who, while being treated with corticosteroids for a myelodysplastic syndrome, developed myositis of the calf due to Aspergillus fumigatus. Despite therapy with amphotericin B the myositis failed to resolve and he died. At autopsy, a localized necrotizing myositis of the right calf was found with no evidence of disseminated Aspergillus infection. Myositis in the setting of disseminated candidiasis or cryptococcosis has been previously reported. This case is unique in that it is the first reported case of localized fungal myositis and of myositis caused by Aspergillus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Arena FP, Perlin M, Brahman H, Weiser B, Armstrong D: Fever, rash, and myalgias of disseminated candidiasis during antifungal therapy. Arch Intern Med 141:1233, 1981.

    Google Scholar 

  2. Arroyo J, Medoff G, Kobayashi GS: Therapy of murine aspergillosis with amphotericin B in combination with rifampin or 5-fluorocytosine. Antimicrob Agents Chemother 11:21–25, 1977.

    Google Scholar 

  3. Casale TB, Macher AM, Fauci AS: Concomitant pulmonary aspergillosis and nocardiosis in a patient with chronic granulomatous disease of childhood. South Med J 77:274–275, 1984.

    Google Scholar 

  4. Chiedozi LC: Pyomyositis: Review of 205 cases in 112 patients. Am J Surg 137:255–259, 1979.

    Google Scholar 

  5. Diggs CH, Eskenasy GM, Sutherland JC, Wiernik PH: Fungal infection of muscle in acute leukemia. Cancer 38:1771–1772, 1976.

    Google Scholar 

  6. Gibson RK, Rosenthal SJ, Lukert BP: Pyomyositis. Increasing recognition in temperate climates. Am J Med 77:768–772, 1984.

    Google Scholar 

  7. Jarowski CI, Fialk MA, Murray HW, Gottlieb GJ, Coleman M, Steinberg CR, Silver RT: Fever, rash and muscle tenderness: A distinctive clinical presentation of disseminated candidiasis. Arch Intern Med 138:544–548, 1978.

    Google Scholar 

  8. Jimenez-Lucho VE, Del Busto R, Fisher EJ: Disseminated cryptococcosis with muscular involvement. J Infect Dis 151:567, 1985.

    Google Scholar 

  9. Kitahara M, Seth VK, Medoff G, Kobayashi GS: Activity of amphotericin B, 5-fluorocytosine, and rifampin against six clinical isolates of Aspergillus. Antimicrob Agents Chemother 9:915–919, 1976.

    Google Scholar 

  10. Ledford DK, Overman MD, Gonzalvo A, Cali A, Mester SW, Lockey RF: Microsporidiosis myositis in a patient with the acquired immunodeficiency syndrome. Ann Intern Med 102:628–630, 1985.

    Google Scholar 

  11. Meyer RD, Young LS, Armstrong D, Yu B: Aspergillosis complicating neoplastic disease. Am J Med 54:6–15, 1973.

    Google Scholar 

  12. Schlech WF, Moulton P, Kaiser AB: Pyomyositis: Tropical disease in a temperature climate. Am J Med 71:900–902, 1981.

    Google Scholar 

  13. Young RC, Bennett JE, Vogel CL, Carbone PP; De Vita VT: Aspergillosis. The spectrum of the disease in 98 patients. Medicine 49:147–173, 1970.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reboli, A.C., Reilly, R.F. & Jacobson, R.J. Aspergillus myositis in a patient with a myelodysplastic syndrome. Mycopathologia 97, 117–119 (1987). https://doi.org/10.1007/BF00436849

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00436849

Keywords

Navigation