Skip to main content
SpringerLink
Log in

An electron microscope study of “Pacinian neurofibroma”

  • Published:
Virchows Archiv A Aims and scope Submit manuscript

Summary

An electron microscope study has been made of the “Pacinian neurofibroma”. Unlike the usual neurofibroma the “Pacinian neurofibroma” is characterized by a proliferation of the so-called perineurial cells. Groups of surface vesicles, the absence of mesoaxons and a fragmented basallamina differentiate these perineurial cells from Schwann cells. The formation of the perineurial cells can be traced continuously from small and wide submicroscopic cellbands and clubshaped thickenings to ribbonlike cell complexes as well as to tactile-like structures. The most developed complexes and structures are visible with the light microscope. These formations do not correspond with real tactile corpuscles, rather they can be considered as neoplastic structures of the perineurium.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abrikossoff, A.: Über Myome ausgehend von der quergestreiften willkürliche Muskulatur. Virchows Arch. path. Anat. 260, 245–238 (1926)

    Google Scholar 

  • Abrikossoff, A.: Weitere Untersuchungen über Myoblastenmyome. Virchows Arch. path. Anat. 280, 723–740 (1931)

    Google Scholar 

  • Ackerman, L. V., Rosai, J.: Surgical pathology, 1128 pp. St. Louis, Mo.: C. V. Mosby Co. 1974

    Google Scholar 

  • Brögli, M.: Ein Fall von Rankenneurom mit Tastkörperchen. Prankfurt. Z. Path. 41, 595–610 (1931)

    Google Scholar 

  • Cauna, N., Ross, L. L.: The fine structure of Meissner's touch corpuscles of human fingers. J. biophys. biochem. Cytol. 8, 467–482 (1960)

    Google Scholar 

  • Cervos-Navarro, J., Matakas, F., Lazaro, M. C.: Das Bauprinzip der Neurinome. Ein Beitrag zur Histogenese der Nerventumoren. Virchows Arch. Abt. A 345, 276–291 (1968)

    Google Scholar 

  • Denny-Brown, D.: Importance of neural fibroblasts in the regeneration of nerve. Arch. Neurol. Psychiat. (Chic.) 55, 171–215 (1946)

    Google Scholar 

  • Feyrter, F.: Über eine eigenartige Geschwulstform des Nervengewebes im menschlichen Verdauungsschlauch. Virchows Arch. path. Anat. 295, 480–501 (1935)

    Google Scholar 

  • Feyrter, F.: Über den Naevus. Virchows Arch. path. Anat. 301, 417–469 (1938)

    Google Scholar 

  • Feyrter, F.: Über die granulären neurogenen Gewächse. Beitr. path. Anat. 110, 181–208 (1949)

    Google Scholar 

  • Feyrter, F.: Über die granulären Neurome (sog. Myoblastenmyome). Virchows Arch. path. Anat. 322, 66–72 (1952)

    Google Scholar 

  • Fisher, E. R., Vuzevski, V. D.: Cytogenesis of Schwannoma (Neurilemoma), Neurofibroma, Dermatofibroma, and Dermatofibrosarcoma as revealed by electron microscopy. Amer. J. clin. Path. 49, 141–154 (1968)

    Google Scholar 

  • Fisher, E. R., Wechsler, H.: Granular cell myoblastoma—a misnomer. Cancer (Philad.) 15, 936–954 (1962)

    Google Scholar 

  • Gamble, H. J.: Comparative electron-microscopic observations on the connective tissues of a peripheral nerve and a spinal nerve root in the rat. J. Anat. (Lond.) 98, 17–25 (1964)

    Google Scholar 

  • Gamble, H. J., Breathnach, A. S.: An electron-microscope study of human foetal peripheral nerves. J. Anat. (Lond.) 99, 573–584 (1965)

    Google Scholar 

  • Gamble, H. J., Eames, R. A.: An electron microscope study of the connective tissues of human foetal peripheral nerves. J. Anat. (Lond.) 98, 655–633 (1964)

    Google Scholar 

  • Garancis, J. C., Komorowski, R. A., Kuzma, J. P.: Granular all myoblastoma. Cancer (Philad.) 25, 542–550 (1970)

    Google Scholar 

  • Gruner, J. E.: Les lésions élémentaires de la neurofibromatose de Recklinghausen. Etude au microscope electronique. Rev. neurol. 102, 525–529 (1960)

    Google Scholar 

  • Hill, R. P.: Neuroma of Wagner-Meissner Tactile corpuscles. Cancer (Philad.) 4, 879–882 (1951)

    Google Scholar 

  • Jordan, P.: Tastkörperartige Bildungen in einem zelligen Naevus der behaarten Kopfhaut. Zur Kenntnis des Neuronaevus, des Neurinoms, des Psammoms, der Cutis und Pseudo-Cutis verticis gyrata und der Recklinghausenschen Krankheit. Arch. Derm. Syph. (Berl.) 169, 105–126 (1933)

    Google Scholar 

  • Lassmann, H., Ammerer, H. P.: Schwann Cells and Perineurium in Neuroma. Virohows Arch. Abt. B 15, 313–321 (1974)

    Google Scholar 

  • Lehman, H. J.: Über Struktur und Funktion der perineuralen Diffusionsbarriere. Z. Zellforsch. 46, 232–241 (1957)

    Google Scholar 

  • Lehman, H. J.: Die Nervenfaser. In: Handbuch der mikroskopischen Anatomie des Menschen, Bd. IV/I. Ed. W. Bargman. Berlin-Heidelberg-New York: Springer 1959

    Google Scholar 

  • Luse, S. A.: Electron microscopic studies of brain tumors. Neurology (Minneap.) 10, 881–905 (1960)

    Google Scholar 

  • Luse, S. A.: Electron microscopy of brain tumors. In: W. S. Fields and P. C. Sharkey, The biology and treatment of intercranial tumors. Springfield: Ch. C. Thomas 1962

    Google Scholar 

  • Mikuz, G., Propst, A.: Über vasculäre Neurofibromatose. Virchows Arch. Abt. A 356, 173–185 (1972)

    Google Scholar 

  • Nishi, K., Oura, C., Pallie, W.: Fine structure of Pacinian corpuscles in the mesentery of the cat. J. Cell Biol. 43, 539–552 (1969)

    Google Scholar 

  • Nürnberger, F., Müller, G., Rockert, H.: Zur Ultrastruktur des Neurofibroms. Arch. klin. exp. Derm. 237, 796–799 (1970)

    Google Scholar 

  • Pineda, A.: Submicroscopic structure of acoustic tumors. Neurology (Minneap.) 14, 171–184 (1964a)

    Google Scholar 

  • Pineda, A.: Neurolemmomas. Trans. Amer, neurol. 89, 241–242 (1964b)

    Google Scholar 

  • Pineda, A.: Collagen formation by principal cells of acoustic tumors. Neurology (Minneap.) 15, 536–547 (1965)

    Google Scholar 

  • Pineda, A.: Electron microscopy of the tumor cells in “neurofibromas”. J. Neuropath. exp. Neurol. 25, 158–159 (1966)

    Google Scholar 

  • Pineda, A.: The fine structure of peripheral nerve tumors, current concepts. At the VI. Int. Congr. Neuropath. 1970

  • Poirier, J., Escourolle, R., Casthigne, P.: Les neurofibromes de la maladie de Recklinghausen. Etude ultrastructurale et place nosologique par rapport aux neurinomes. Acta neuropath. (Berl.) 10, 279–294 (1968)

    Google Scholar 

  • Polacek, P., Mazanec, L.: Ultrastructure of mature Pacinian corpuscles from the mesentery of adult cat. Z. mikr.-anat. Forsch. 75, 343–354 (1966)

    Google Scholar 

  • Prichard, R. W., Custer, R. Ph.: Pacinian-neurofibroma. Cancer (Philad.) 5, 297–301 (1952)

    Google Scholar 

  • Röhlich, P., Knoop, A.: Elektronenmikroskopische Untersuchungen an den Hüllen des N. Ischiadicus der Ratte. Z. Zellforsch. 53, 299–312 (1961)

    Google Scholar 

  • Saxen, E.: Tumours of tactile end-organs. Acta path, microbiol. scand. 25, 66–79 (1948)

    Google Scholar 

  • Schochet, S. S., Barrett, D. A.: Neurofibroma with aberrant tactile corpuscles. Acta neuropath. (Berl.) 28, 161–165 (1974)

    Google Scholar 

  • Shanthaveerappa, T. R., Bourne, G. H.: The “perineurial epithelium”, a metabolically active, continuous, protoplasmic cell barrier sourrounding peripheral nerve fasciculi. J. Anat. (Lond.) 96, 527–537 (1962)

    Google Scholar 

  • Shanthaveerappa, T. R., Bourne, G. H.: The perineurial epithelium: nature and significance. Nature (Lond.) 199, 577–579 (1963)

    Google Scholar 

  • Shanthaveerappa, T. R., Bourne, G. H.: The perineurial epithelium of sympathetic nerves and ganglion and its relation to the pia-arachnoid mater of the central nervous system and perineurial epithelium of peripheral nerves. Z. Zellforsch. 61, 742–753 (1964)

    Google Scholar 

  • Sobel, H. J., Marquet, E., Avrin, E., Schwarz, R.: Granular cell Myoblastoma. Amer. J. Path. 65, 69–71 (1971)

    Google Scholar 

  • Spencer, P. S., Schaumburg, H. H.: An ultrastructural study of the inner core of the Pacinian corpuscle. J. Neurocytol. 2, 217–235 (1973)

    Google Scholar 

  • Stochdorph, O.: Über Gewebsbilder von Tumoren der peripheren Nerven. Acta neuropath. (Berl.) 4, 245–266 (1965)

    Google Scholar 

  • Stout, A. P.: Tumors of the peripheral nervous system. Atlas of tumor pathology, sect. II, fasc. 6. Washington, D. C.: Armed Forces Institute of Pathology 1949

    Google Scholar 

  • Thomas, P. K., Jones, O. G.: The cellular response to nerve section. J. Anat. (Lond.) 101, 45–55 (1967)

    Google Scholar 

  • Waggener, J. D.: Ultrastructure of benign peripheral nerve sheat tumors. Cancer (Philad.) 19, 699–709 (1966)

    Google Scholar 

  • Waggener, J. D., Bunn, S. M., Beggs, J.: Diffusion of ferritin within the peripheral nerve sheat. J. Neuropath, exp. Neurol. 24, 430–454 (1965)

    Google Scholar 

  • Weber, K., Braun-Falco, O.: Zur Ultrastruktur der Neurofibromatose. Hautarzt 23, 116–122 (1972)

    Google Scholar 

  • Wechsler, W., Hossmann, K. A.: Zur Feinstruktur menschlicher Acusticusneurinome. Beitr. path. Anat. 132, 319–343 (1965)

    Google Scholar 

  • Weiser, G., Propst, A.: Elektronenoptische Untersuchung zur Histogenese des Granulären Neuroms. Virchows Arch. Abt. A 358, 193–204 (1973)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Innsbruck, Austria

    G. Weiser

Authors
  1. G. Weiser
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weiser, G. An electron microscope study of “Pacinian neurofibroma”. Virchows Arch. A Path. Anat. and Histol. 366, 331–340 (1975). https://doi.org/10.1007/BF00433892

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00433892

Keywords

Search

Navigation