Abstract
d-Amphetamine and phencyclidine (PCP) have both been reported to produce manic-like sequela in humans, effects that are reportedly antagonized by lithium. To test the hypothesis that the acute effects of these drugs in rats may serve as models of mania, the behaviors, induced by d-amphetamine (3 mg/kg) or PCP (5 mg/kg) were quantified on behavioral rating scales subsequent to chronic dietary pretreatment with lithium carbonate or control diet. On day 14 of pretreatment, PCP-induced stereotyped behaviors and ataxia were potentiated in rats receiving lithium (plasma levels 1.0±0.23 mEq/l). PCP-induced locomotor activity was not affected by lithium pretreatment. Stereotypies and locomotion induced by d-amphetamine were also not significantly affected by lithium pretreatment. These results suggest that neither PCP nor amphetamine administered acutely to rats will be useful models to explore the manic-like symptoms produced by these drugs in humans.
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References
Berggren U, Tallstedt L, Ahlenius S, Engel J (1978) The effect of lithium on amphetamine-induced locomotor stimulation. Psychopharmacology 59:41–45
Besson MJ, Cheramy A, Feltz P, Glowinski J (1971) Dopamine: Spontaneous and drug-induced release from caudate nucleus of the cat. Brain Res 32:407–425
Borison RL, Sabelli HC, Maple PJ, Havdala HS, Diamond BI (1978) Lithium prevention of amphetamine-induced manic excitement and of reserpine-induced depression in mice: Possible role of 2-phenethylamine. Psychopharmacology 59:259–262
Costall B, Naylor RJ (1974) Extrapyramidal and mesolimbic involvement with the stereotypic activity of d-and l-amphetamine. Eur J Pharmacol 25:121–219
D'Encarnacao PS, Anderson K (1970) Effects of lithium pretreatment on amphetamine and DMI psychomotor behavior. Dis Nerv Syst 31:494–496
Ferris RM, Tang FLM, Maxwell RA (1972) A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex hypothalamus and striatum into adrenergic nerves of rabbit cortex. J Pharmacol Exp Ther 181:407–416
Fessler RG, Sturgeon RD, Meltzer HY (1981) Effects of phencyclidine and methylphenidate on d-amphetamine-induced behavior in reserpine-treated rats. Pharmacol Biochem Behav 13:835–842
Flemenbaum A (1974) Does lithium block the effects of amphetamines? A report of three cases. Am J Psychiatry 131:820–821
Friedman E, Gershon S (1973) Effect of lithium on brain dopamine. Nature 243:520–521
Furukawa T, Ushizima I, Ono N (1975) Modifications by lithium of behavioral responses to methamphetamine and tetrabenazine. Psychopharmacologia 42:243–248
Gershon S, Shopsin B (1973) Lithium. Plenum, New York
Hasketh JE, Nicholou NM, Arbuthnott GW, Wright AK (1978) The effect of chronic lithium administration on dopamine metabolism in rat striatum. Psychopharmacology 56:163–166
Matussek N, Linsmayer M (1968) The effect of lithium and amphetamine on desmethylimipramine-and RO4-1284-induced motor, hyperactivity. Life Sci 7:371–375
Meltzer HY, Sturgeon RD, Simonovic M, Fessler RG (1981) Phencyclidine as an indirect dopamine agonist.. In: Domino EF (ed) PCP (phencyclidine): Historical and current perspectives. NPP Books, Ann Arbor, pp 207–242
Ozawa H, Miyauchi T (1977) Potentiating effect of lithium chloride on methamphetamine-induced stereotypy in mice. Eur J Pharmacol 41:213–216
Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL (1971) Stimulation of serotonin synthesis by lithium. J Pharmacol E Ther 178:325–350
Poitou P, Guerinot F, Bohron C (1974) Effect of lithium on central metabolism of 5-hydroxytryptamine. Psychopharmacology 38: 75–80
Schou M (1958a) Lithium studies. I. Toxicity. Acta harmacol Toxicol (Copenh) 15:70–84
Schou M (1958b) Lithium studies. II. Renal elimination. Acta Pharmacol Toxicol 15:85–98
Schou M (1968) Lithium in psychiatric therapy and prophylaxis. J Psychiatr Res 6:67–95
Schubert J (1973) Effect of chronic lithium treatment on monoamine metabolism in rat brain. Psychopharmacologia 32:301–311
Segal DS, Callaghan M, Mandell A (1975) Alterations in behavior and catecholamine biosynthesis induced by lithium. Nature 254:58–59
Shaw JP, Ratcliffe E (1976) Effect of lithium on brain 5-hydroxytryptamine metabolism in mice. Arch Int Pharmacodyn Ther 222:116–124
Slavney PR, Rich GB, Pearlson GD, McHugh PR (1978) Phencyclidine abuse and symptomatic mania. Biol Psychiatry 12:697–700
Smith RC, Meltzer HY, Arora RC, Davis JM (1977) Effects of phencyclidine on 3H-catecholamine and 3H-serotonin uptake in synaptosomal preparations from rat brain. Biochem Pharmacol 26:1435–1439
Sturgeon RD, Fessler RG, Meltzer HY (1979) Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats. Eur J Pharmacol 59:169–179
Thomsen K (1973) The effect of sodium chloride on kidney function in rats with lithium intoxication. Acta Pharmacol Toxicol (Copenh) 33:92–102
U'Prichard DC, Steinberg H (1972) Selective effects of two forms of spontaneous activity. Br J Pharmacol 44:349–350
Van Kammen DP, Murphy DL (1975) Attenuation of the euphoriant and activating effects of d-and l-amphetamine by lithium carbonate treatment. Psychopharmacologia 44:215–244
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Fessler, R.G., Sturgeon, R.D., London, S.F. et al. Effects of lithium on behaviour induced by phencyclidine and amphetamine in rats. Psychopharmacology 78, 373–376 (1982). https://doi.org/10.1007/BF00433745
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DOI: https://doi.org/10.1007/BF00433745