Abstract
The startle response to an auditory atimulus was potentiated by treatment with d-amphetamine sulfate. Administration of l-dopa after pretreatment with the extracerebral decarboxylase inhibitor MK-486 also increased startle activity. After long-term exposure to amphetamine the startle response to l-dopa and d-amphetamine was enhanced. These findings are consistent with the consequences of longterm amphetamine administration on other amphetamine-induced behaviors (e.g. stereotypy), and are discussed in terms of the effects of long-term amphetamine treatment on pre-and postsynaptic dopamine receptors and serotonin.
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Kokkinidis, L., MacNeill, E.P. Potentiation of d-amphetamine and l-dopa-induced acoustic startle activity after long-term exposure to amphetamine. Psychopharmacology 78, 331–335 (1982). https://doi.org/10.1007/BF00433736
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DOI: https://doi.org/10.1007/BF00433736