Abstract
Alcohol-accepting (AA) and alcohol-nonaccepting (ANA) rats (Alko, Finland) were tested for their ability to master a shock-motivated (0.6 mA scrambled AC current) T-maze discrimination in which IP injections of ethanol (1.0 g/kg, 10% w/v in saline, 20-min latency) and, on alternate days, equivolume saline were employed as a discriminative stimuli signalling the safety of right or left goal compartments. ANA rats reached the criterion level of performance (eight of ten correct first-trial responses) more quickly than did AA rats (12.3±2.3 versus 31.4±7.7 sessions, P<0.01) and also maintained a superior level of performance throughout the course of the experiment, suggesting that ethanol may have been a more salient cue for ANA rats than for AA rats. Injections of acetaldehyde (0.1–0.25 g/kg, 1.0–2.5% w/v in saline) produced ethanol-appropriate responding to a greater extent in ANA rats than in AA rats, indicating that the actions of acetaldehyde may contribute importantly to the stimulus condition produced by the injection of ethanol in ANA rats. Sodium pentobarbital (10.0 g/kg) was equally effective in mimicking the action of ethanol in both AA and ANA rats. AA and ANA rats did not differ significantly in the impairment of motor performance produced by a range of ethanol doses, suggesting that differences in stimuli related to motor impairment do not contribute to the differences observed in the cue value of ethanol for AA and ANA rats.
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References
Abel EL, York JL (1979) Age-related differences in response to ethanol in the rat. Physiol Psychol 7:391–395
Barry III H (1974) Classification of drugs according to their discriminable effects in rats. Fed Proc 33:1814–1824
Colpaert FL, Rosecrans JA (eds) (1978) Stimulus properties of drugs: Ten years of progress. Elsevier/North Holland Biomedical Press, Amsterdam
Erickson CK, Lau AS, Schulz JD, Matchett JA (1975) A time-course and dose-response study of the relationship between brain acetaldehyde, norepinephrine, and locomotor activity after ethanol in mice. In: Lindros KO, Eriksson CJP (eds) The role of acetaldehyde in the actions of ethanol. The Finnish Foundation for Alcohol Studies, Helsinki, pp 177–186
Eriksson CJP (1973) Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference. Biochem Pharmacol 22:2283–2292
Eriksson CJP (1980) The aversive effect of acetaldehyde on alcohol drinking behavior in the rat. Alcohol Clin Exp Res 4:107–112
Eriksson K (1969) Factors affecting voluntary alcohol consumption in the rat. Ann Zool Fennici 6:227–265
Eriksson K (1978) Finnish selection studies on alcohol-related behaviors: General outline. Paper presented at the Selective Breeding Conference, Boulder, Colorado. The Finnish Foundation for Alcohol Studies, Helsinki
Forsander OA, Eriksson CJP (1972) Metabolic characteristics of rat strains consuming different amounts of alcohol. In: Forsander O, Eriksson K (eds) Biological aspects of alcohol consumption. The Finnish Foundation for Alcohol Studies, Helsinki, pp 43–49
Ho BT, Richards III DW, Chute DL (eds) (1978) Drug discrimination and state-dependent learning. Academic Press, New York
Lal H (ed) (1977) Discriminative stimulus properties of drugs. Plenum Press, New York
Lumeng L, Hawkins TD, Li TK (1977) New strains of rats with alcohol preference and nonpreference. In: Thurman RG, Williamson JR, Drott H, Chance B (eds) Alcohol and aldehyde metabolizing systems, Vol III. Academic Press, New York, pp 537–544
Malila A (1978) Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake. Pharmacol Biochem Behav 8:197–201
McClearn GE, Rodgers DA (1959) Differences in alcohol preference among inbred strains of mice. Q J Stud Alcohol 20:691–695
McClearn GE, Rodgers DA (1961) Genetic factors in alcohol preference of laboratory mice. J Comp Physiol Psychol 54:116–119
Nikander P, Pekkanen L (1977) An inborn alcohol tolerance in alcohol-preferring rats. The lack of relationship between tolerance to ethanol and the brain microsomal (Na+K+) ATPase activity. Psychopharmacology 51:219–223
Overton DA (1972) State-dependent learning produce by alcohol and its relevance to alcoholism. In: Kissin B, Begleiter H (eds) The biology of alcoholism, Vol 2. Plenum Press, New York, pp 193–214
Overton DA (1974) Experimental methods for the study of state-dependent learning. Fed Proc 33:1800–1813
Schlesinger K (1966) Genetic biochemical correlates of alcohol preference in mice. Am J Psychiatry 122:767–776
Schlesinger K, Kakihana R, Bennett EL (1966) Effects of tetraethylthiuramidisulfide (Antabuse) on metabolism and consumption of ethanol in mice. Psychosom Med 28:514–520
Sheppard JR, Albersham P, McClearn GE (1966) Enzyme activities and ethanol preference in mice. Biochem Genet 2:205–212
Tottmar O, Marchner H (1975) Characteristics of the acetaldehyde oxidation in rat liver, and the effects of Antabuse, 4-methylpyrazole and unknown dietary factors on the hepatic output of acetaldehyde. In: Kindros KO, Eriksson CJP (eds) The role of acetaldehyde in the actions of ethanol. The Finnish Foundation for Alcohol Studies, Helsinki, pp 177–186
Winter JC (1978) Drug-induced stimulus control. In: Blackman DE, Sanger DJ (eds) Contemporary research in behavioral pharmacology. Plenum Press, New York, pp 209–234
York JL (1978) Efficacy of ethanol as a discriminative stimulus in ethanol-preferring and ethanol-nonpreferring rats. Experientia 34:224–225
York JL (1981) Consumption of intoxicating beverages by rats and mice exhibiting high and low preferences for ethanol. Pharmacol Biochem Behav 15 (in press)
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York, J.L. The ethanol stimulus in rats with differing ethanol preferences. Psychopharmacology 74, 339–343 (1981). https://doi.org/10.1007/BF00432743
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DOI: https://doi.org/10.1007/BF00432743