Abstract
Twelve volunteers with a complaint of chronic insomnia participated in a placebo-controlled, doubleblind, crossover study of the effects of buspirone t.i.d. on sleep pattern and daytime function. The drug was tested alone and in combination with flurazepam or triazolam. Buspirone alone did not impair objective measures of daytime wakefulness or performance. Impaired alertness was seen the day after bedtime administration of flurazepam but not after triazolam; buspirone did not alter these effects. Buspirone did not affect the Multiple Sleep Latency Test, a sensitive measure of changes in daytime alertness.
References
Angel JE (1984) Physician's Desk Reference. Medical Economics Co. Inc. Oradell, New Jersey
Bliwise D, Seidel WF, Caracan I, Mitler MM, Roth T, Zorick F, Dement WC (1983). Daytime sleepiness as a criterion in hypnotic drug trials: comparison of triazolam and flurazepam. Sleep 6:156–163.
Carskadon MA (ed) (1982) Perspectives on daytime sleepiness. Sleep 5 (suppl 2):s55-207
Cole JO, Orzack MH, Beake B, Bird M, Bar-Tal Y (1982) Assessment of the abuse liability of buspirone in recreational sedative users. J Clin Psychiatry 43:69–75
Dement WC, Seidel WF, Carskadon MA (1982) Daytime alertness, insomnia, and benzodiazepines. Sleep 5:s28–45
Feighner JP, Merideth CH, Hendrickson GA (1982) A doubleblind comparison of buspirone and diazepam in outpatients with generalized anziety disorder. J Clin Psychiatry 43:103–107
Goldberg HL (1984) Buspirone hydrochloride: A unique new anxiolytic agent. Pharmacotherapy 4:315–324
Goldberg HL, Finnerty R (1982) Comparison of buspirone in two separate studies. J Clin Psychiatry 43:87–91
Honkanen R, Ertama L, Linoila M, Alha A, Lukkari I, Karlsson M, Kiviluoto O, Puro M (1980) Role of drugs in traffic accidents. Br Med J 281:1309
Lader M (1982) Psychological effects of buspirone. J Clin Psychiatry 43:62–67
Mattila MJ, Aranko K, Seppala T (1982) Acute effects of buspirone and alcohol on psychomotor skills. J Clin Psychiatry 43:56–60
Moskowitz H, Smiley A (1982) Effects of chronically administered buspirone and diazepam on driving-related skills and performance. J Clin Psychiatry 43:45–55
Rechtschaffen A, Kales A (eds) (1968) A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects. Brain Information Service/Brain Research Institute, University of California at Los Angeles. California
Seidel WF, Roth T, Roehrs T, Zorick F, Dement WC (1984) Treatment of a 12-hour shift of sleep schedule with benzodiazepines. Science 224:1262–1264
Skolnick P, Paul SM, Weismann BA (1984) Preclinical pharmacology of buspirone hydrochloride. Pharmacotherapy 4:308–314
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Seidel, W.F., Cohen, S.A., Bliwise, N.G. et al. Buspirone: An anxiolytic without sedative effect. Psychopharmacology 87, 371–373 (1985). https://doi.org/10.1007/BF00432724
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DOI: https://doi.org/10.1007/BF00432724