Summary
The results are presented of a clinical-enzyme histochemical evaluation of the activity of acetylcholinesterase in the rectal mucosa of 46 children with obstipation. In four cases abundant and coarse acetylcholinesterase positive nerve fibres were present in the lamina propria of the mucosa. Only in these 4 cases was the diagnosis of Hirschsprung's disease supported by the clinical course.
Local accumulations of fine acetylcholinesterase positive nerve fibres or accumulations of acetylcholinesterase positive foamy or structureless material were not correlated with Hirschsprung's disease.
Similar content being viewed by others
References
Brestkin, A.P., Ivanova, L.A.: Effect of Li and Ca ions on the activity of erythrocyte acetylcholines-terase. Biokimia 35, 652–656 (1970)
Dobbins, W.O., Bill, A.H.: Diagnosis of Hirschsprung's disease excluded by rectal suction biopsy. New Engl. J. Med. 272, 990–993 (1965)
Karnovsky, M.J., Roots, L.A.: A “direct-coloring” thiocholine method for cholinesterase. J. Histochem. Cytochem. 12, 219–221 (1964)
Meier-Ruge, W.: Das Megacolon, seine Diagnose und Pathophysiologie. Virchows Arch. Abt. A Path. Anat. 344, 67–85 (1968)
Meier-Ruge, W.: Hirschsprung's disease. Its aetiology, pathogenesis and differential diagnosis. Current Top. Pathol. 59, 131–179 (1974)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Toorman, J., Bots, G.T.A.M. & Vio, P.M.A. Acetylcholinesterase-activity in rectal mucosa of children with obstipation. Virchows Arch. A Path. Anat. and Histol. 376, 159–164 (1977). https://doi.org/10.1007/BF00432586
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00432586