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Frequency and morphology of malignant tumours of the thyroid before and after the introduction of iodine-prophylaxis

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Summary

Reclassification of malignant goitres surgically removed between 1952–1975 reveals remarkable epidemiological alterations. There is a proportional decrease in undifferentiated carcinoma, which in males also represents an absolute decrease. The decrease is due to a change in maximum incidence from the 5th to the 7th decade. Differentiated carcinomas, especially the papillary tumours, increase.

Comparison with findings in Switzerland shows many conformities. Iodine-prophylaxis apparently influences the morphology of thyroid carcinoma, as indicated by the time lag between the introduction of iodine-prophylaxis and the appearance of alterations in incidence. Iodine-prophylaxis, acting in this way, will improve survival rates in thyroid cancer.

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  1. Pathologisches Institut der Universität Innsbruck, Müllerstrasse 44, A-6020, Innsbruck, Austria

    Ferdinand Hofstädter

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  1. Ferdinand Hofstädter
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Hofstädter, F. Frequency and morphology of malignant tumours of the thyroid before and after the introduction of iodine-prophylaxis. Virchows Arch. A Path. Anat. and Histol. 385, 263–270 (1980). https://doi.org/10.1007/BF00432536

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  • DOI: https://doi.org/10.1007/BF00432536

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