Skip to main content
SpringerLink
Log in

Assessing pharmacologically induced dopamine receptor sensitivity changes with the ungerstedt turning model

  • Short Reports
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Rats were lesioned unilaterally in the substantia nigra with 6-hydroxydopamine. Turning in response to apomorphine and amphetamine was assessed before and 5 days after 3-week treatment with haloperidol. After haloperidol withdrawal, contralateral turning, measured at 5 min following IP injection of 1 mg/kg apomorphine, was significantly less than before haloperidol treatment and ipsilateral turning, measured at 30 min following IP injection of 2 mg/kg amphetamine, was significantly greater than before the haloperidol treatment. These results suggest that dopamine receptor sensitivity increased on the unlesioned side compared to the lesioned side.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Burt DR, Creese I, Snyder SH (1977) Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain. Science 197:326–328

    Google Scholar 

  • Creese I, Burt DR, Snyder SH (1977) Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Science 197:596–598

    Google Scholar 

  • König JFR, Klippel RA (1963) The rat brain: A stereotaxic atlas of forebrain and lower parts of the brain stem. Krieger, New York

    Google Scholar 

  • Müller P, Seeman P (1977) Brain neurotransmitter receptors after longterm haloperidol: Dopamine, acetylcholine, serotonin, alphanoradrenergic and naloxone receptors. Life Sci 21:1751–1758

    Google Scholar 

  • Tarsy D, Baldessarini RJ (1974) Behavioral supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines. Neuropharmacology 13:927–940

    Google Scholar 

  • Ungerstedt U (1971) Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior Acta Physiol Scand (Suppl) 82:49–68

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Neuropharmacology Branch, National Institute of Mental Health, 20205, Bethesda, Maryland, USA

    Larry Siever & Robert Cohen

  2. Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, Maryland, USA

    Agu Pert

Authors
  1. Larry Siever
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Agu Pert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siever, L., Cohen, R. & Pert, A. Assessing pharmacologically induced dopamine receptor sensitivity changes with the ungerstedt turning model. Psychopharmacology 75, 212–213 (1981). https://doi.org/10.1007/BF00432190

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00432190

Key words

Search

Navigation