Abstract
Post-training intrahippocampal injection of the dopaminergic agonists apomorphine and ergometrine improved retention in a brightness discrimination task. The dopamine receptor blocker haloperidol caused an impairment of retention and antagonized improvement by apomorphine. An involvement of hippocampal dopaminergic mechanisms in memory consolidation processes was suggested.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Adey WR (1967) Hippocampal states and functional relations with cortico-subcortical systems in attention and learning. Prog Brain Res 27:228–245
Ahlenius S, Engel J (1975) Antagonism by haloperidol of the l-dopa-induced disruption of a successive discrimination in the rat. J Neural Transm 36:43–49
Bischoff S, Scatton B, Korf J (1979) Biochemical evidence for a transmitter role of dopamine in the rat hippocampus. Brain Res 165:161–165
Bureš J, Burešová O, Weiss T (1960) Functional consequences of hippocampal spreading depression. Physiol Bohemoslov 9:219–227
Dismuke RK, Rake AV (1972) Involvement of biogenic amines in memory formation. Psychopharmacologia 23:17–25
Evangelista AM, Izquierdo I (1971) The effect of pre- and post-trial amphetamine injections on avoidance responses of rats. Psychopharmacologia 20:42–47
Fulginiti S, Molina VA, Orsingher OA (1976) Inhibition of catecholamine biosynthesis and memory processes. Psychopharmacology 51:65–69
Grecksch G, Ott T, Matthies H (1978a) Influence of post-training intrahippocampally applied oxotremorine on the consolidation of a brightness discrimination. Pharmacol Biochem Behav 8:215–218
Grecksch G, Wetzel W, Matthies H (1978b) Effect of n-dipropylacetate on the consolidation of a brightness discrimination. Pharmacol Biochem Behav 9:269–271
Haycock JW, van Buskirk R, Gold PE (1977a) Effects on retention of post-training amphetamine injections in mice: Interactions with pretraining experience. Psychopharmacology 54:21–24
Haycock JW, van Buskirk R, Ryan JR, McGaugh JL (1977b) Enhancement of retention with centrally administered catecholamines. Exp Neurol 54:199–208
Isaacson RL (1972) Hippocampal destruction in man and other animals. Neuropsychologia 10:47–64
Jork R, Lössner B, Matthies H (1979) Dopamine and macromolecule synthesis in rat hippocampus. Pharmacol Biochem Behav 11:247–249
Jork R, Grecksch G, Jirka M, Lössner B, Matthies H (1980) Apomorphine and glycoproteine synthesis in rat hippocampus. Pharmacol Biochem Behav 12:317–318
Landfield PW, Tusa RJ, McGaugh JL (1973) Effects of post-trial hippocampal stimulation on memory storage and EEG activity. Behav Biol 8:485–505
Lauzi-Gozzani J, Izquierdo I (1976) Possible peripheral adrenergic and central dopaminergic influences in memory consolidation. Psychopharmacologia 49:109–111
Lissak K, Endröczi E (1967) Involvement of libic structures in conditioning, motivation and recent memory. Prog Brain Res 27:246–253
McGaugh JL, Petrinovich LF (1965) Effects of drugs on learning and memory. Int Rev Neurobiol 8:139–196
Olds J (1972) Learning and the hippocampus. Rev Can Biol (Suppl) 31:215–238
Ott T (1977) Mechanismen der Gedächtnisbildung, Verhaltens-physiologische und pharmakologische Studie. In: Bureš J, John ER, Kostjuk PG, Pickenhain L (eds) Brain and behaviour research monograph series, Vol 7. VEB Gustav Fischer Verlag Jena
Ott T, Dosske A, Thiemann W, Matthies H (1972) Eine teilautomatische Lernanlage für optische Diskriminierungsreaktionen mit Ratten. Acta Biol Med Ger 29:103–108
Ott T, Schmitt M, Krug M, Matthies H (1974) Intrahippocampal injection of chemicals: Analysis of spread. Pharmacol Biochem Behav 2:715–718
Pohle W, Rüthrich HL, Popov N, Matthies H (1979) Fucose incorporation into rat hippocampus structures after acquisition of a brightness discrimination. Acta Biol Med Ger 38:53–63
Popov N, Schulzeck S, Pohle W, Matthies H (1980) Changes in 3H-fucose incorporation into rat hippocampus after acquisition of a brightness discrimination reaction. An electrophoretic study. Neuroscience 5:161–167
Simon H, Le Moal M, Calas A (1979) Efferents and afferents of the ventral tegmental — A10 region studied after local injection of 3H-leucine and horseradish peroxidase. Brain Res 178:17–40
Skinner IE (1971) Neuroscience: A laboratory manual. W. S. Saunders, London
Smialowski A (1976) The effect of intrahippocampal administration of dopamine or apomorphine on EEG of limbic structures in the rabbit brain. Pol J Pharmacol Pharm 28:579–585
Swanson LW, Hartman BK (1975) The central adrenergic system: An immunofluorescence study of the location of cell bodies and their afferent connections in the rat utilizing dopamine-β-hydroxylase as a marker. J Comp Neurol 163:467–506
Votava Z, Ott T (1979) The EEG effect of hippocampal apomorphine administration in rats. In: Matthies H, Krug M, Popov N (eds) Biological aspects of learning, memory formation and ontogeny of the CNS. Akademie Verlag, Berlin pp 471–477
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Grecksch, G., Matthies, H. The role of dopaminergic mechanisms in the rat hippocampus for the consolidation in a brightness discrimination. Psychopharmacology 75, 165–168 (1981). https://doi.org/10.1007/BF00432180
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00432180