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Hallucinogenic agents as discriminative stimuli: A correlation with serotonin receptor affinities

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Abstract

A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r=-0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry School of Pharmacy, Virginia Commonwealth University, 23298, Richmond, Virginia, USA

    Richard A. Glennon & Richard Young

  2. Department of Pharmacology, Medical College of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia, USA

    John A. Rosecrans & Mary J. Kallman

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  1. Richard A. Glennon
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  2. Richard Young
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  3. John A. Rosecrans
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  4. Mary J. Kallman
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Glennon, R.A., Young, R., Rosecrans, J.A. et al. Hallucinogenic agents as discriminative stimuli: A correlation with serotonin receptor affinities. Psychopharmacology 68, 155–158 (1980). https://doi.org/10.1007/BF00432133

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  • DOI: https://doi.org/10.1007/BF00432133

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