Abstract
Serum concentrations of cis(Z)-flupentixol have been measured in patients on cis(Z)-flupentixol decanoate injections during successive dosage intervals of 2–4 weeks. The calculation of the fluctuation of the serum concentration in the dosage interval indicates that each individual patient should have his own dosage interval. For the 2-week group a significant correlation was found between weekly dose and preinjection concentration (r=0.79) although an interindividual variability of ×4 was found. For this group the relative within-patient variation in the pre-injections concentration was calculated to be 9.6%, showing that a constant dosage regimen in the individual patient leads to an almost constant drug load.
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References
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Saikia, J.K., Jørgensen, A. Steady-state serum concentrations after cis (Z)-flupentixol decanoate in viscoleo. Psychopharmacology 80, 371–373 (1983). https://doi.org/10.1007/BF00432123
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DOI: https://doi.org/10.1007/BF00432123