Summary
A tumor in a 37 years old male is described in which the tumor cells appeared to be derived from interdigitating cells normally found in the T-cell area of lymph nodes.
The patient presented with superior vena caval obstruction due to a mediastinal mass, followed by lymph node enlargement and skin lesions leading to death within 4 months.
The tumor cells lacked immune markers for lymphocytic cells. They showed Ia-like antigens and high adenosine triphosphatase activity, while acid phosphatase and α-naphthyl acetate esterase activity was absent. Their fine morphology was strikingly similar to that of interdigitating cells.
A combination of these data led us to the conclusion that this tumor represents a specific subtype of the tumors derived from the mononuclear phagocyte system, namely a sarcoma of interdigitating cells.
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Feltkamp, C.A., van Heerde, P., Feltkamp-Vroom, T.M. et al. A malignant tumor arising from interdigitating cells; Light microscopical, ultrastructural, immuno- and enzyme-histochemical characteristics. Virchows Arch. A Path. Anat. and Histol. 393, 183–192 (1981). https://doi.org/10.1007/BF00431075
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DOI: https://doi.org/10.1007/BF00431075