Summary
Electron microscopic studies of uterine leiomyosarcomas disclose a wide range of differentiation in the neoplastic cells. According to the cytoplasmic appearance undifferentiated, myoblastic, and fibroblast-like cells can be distinguished. Derivation of these cells from mesenchymal cells or poorly developed smooth muscle cells of the myometrium is suggested by the finding of numerous variously differentiated intermediate cell types. The cytoplasm of more differentiated tumour cells usually contains myofilament bundles. Three types of filaments are detected: small, intermediate and thick ones. While the thin ones probably are actin filaments, the intermediate and thick filaments are suggested to represent nonspecific filaments described in a variety of other cell types. Fibroblastic cell types are more often encountered and are usually better differentiated in the premenopausal woman. The possible role of endogeneous hormonal factors on the differentiation process of tumour cells is discussed.
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References
Bennet, T., Cobb, J. L. S.: Studies on the avian gizzard: Morphology and innervation of the smooth muscle. Z. Zellforsoh. 96, 173–185 (1969)
Bergman, R. A.: Uterine smooth muscle fibers in castrate and estrogen-treated rats. J. Cell Biol. 36, 639–648 (1971)
Campbell, G. R., Uehara, Y., Mark, G., Burnstock, G.: Fine structure of smooth muscle cells grown in tissue culture. J. Cell Biol. 49, 21–34 (1971)
Cooke, P. H., Fay, F. S.: Correlation between fiber length, ultrastructure, and the lengthtension relationship of mammalian smooth muscle. J. Cell Biol. 52, 105–116 (1972)
Ferrans, V. J., Robets, W. C.: Structural features of cardiac myxomas. Histology, histochemistry, and electron microscopy. Human Pathology 4, 111–146 (1973)
Gwynn, I., Kemp, R. B., Jones, B. M., Grösohel-Stewart, U.: Ultrastructural evidence for myosin of the smooth muscle type at the surface of trypsin-dissociated embryonic chick cells. J. Cell Sci. 15, 279–289 (1974)
Hall, J. E.: Leiomyosarcoma of the uterus. Obstet. Gynec. 38, 629–630 (1971)
Kelly, R. E., Rice, R. V.: Ultrastructural studies on the contractile mechanism of smooth muscle. J. Cell Biol. 42, 683–694 (1969)
Kempson, R. L., Bari, W.: Uterine sarcomas: classification, diagnosis, and prognosis. Human Pathology 1, 331–349 (1970)
Montague, A. G.-W., Swartz, D. P., Woodruff, J. D.: Sarcoma arising in a leiomyoma of the uterus. Amer. J. Obstet. Gynec. 92, 421–427 (1965)
Needham, D. M., Schoenberg, C. F.: Proteins of the contractile mechanism in vertebrate smooth muscle. In: Handbook of physiology, sect. 6, The alimentary canal, ed. by C. F. Code and W. Heidel, vol. IV, p. 1793–1810. Washington D.C.: The American Physiological Society 1968
Rash, J. E., Biesele, J., Gey, G. O.: Three classes of filaments in cardiac differentiation. J. Ultrastruct. Res. 33, 408–435 (1970)
Rosenbluth, J.: Myosin-like aggregates in trypsin-treated smooth muscle cells. J. Cell Biol. 48, 174–188 (1971)
Ross, R., Klebanoff, S. J.: The smooth muscle cell. I. In vivo synthesis of connective tissue proteins. J. Cell Biol. 50, 159–171 (1971)
Silverberg, S. G.: Leiomyosarcoma of the uterus. Obstet. Gynec. 38, 613–628 (1971)
Taylor, H. B., Norris, H. J.: Mesenchymal tumors of the uterus. IV. Diagnosis and prognosis of leiomyosarcomas. Arch. Path. 82, 40–45 (1966)
Yamauchi, A., Burnstock, G.: Post-natal development of smooth muscle cells in the mouse vas deferens. A fine structural study. J. Anat. (Lond.) 104, 1–15 (1969)
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Böcker, W., Strecker, H. Electron microscopy of uterine leiomyosarcomas. Virchows Arch. A Path. Anat. and Histol. 367, 59–71 (1975). https://doi.org/10.1007/BF00430773
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DOI: https://doi.org/10.1007/BF00430773